2-HYDROXY-3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-HYDROXY-3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER
• CAS No.: 33173-51-2
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.257
• Mol file: 33173-51-2.mol

Synonyms:Lacticacid, 3-(p-methoxyphenyl)-, ethyl ester, D- (8CI); Ethyl(2R)-2-hydroxy-3-(4-methoxyphenyl)propanoate

Chemical Property of 2-HYDROXY-3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 2.57E-05mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 344.1°C at 760 mmHg
• Flash Point: 128°C
• PSA: 55.76000
• Density: 1.137g/cm³
• LogP: 1.16170

Purity/Quality:

98%min ^*data from raw suppliers

(R)-2-Hydroxy-3-(4-methoxy-phenyl)-propionicacidethylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER

There total 2 articles about 2-HYDROXY-3-(4-METHOXY-PHENYL)-PROPIONIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

vinyl acetate (108-05-4,9003-20-7) + ethyl 2-hydroxy-3-(4-methoxyphenyl)propanoate (38618-53-0) → ethyl (R)-2-hydroxy-3-(4-methoxyphenyl)propanoate (33173-51-2) + ethyl (S)-2-acetoxy-3-(4-methoxyphenyl)propanoate (37504-76-0)

Guidance literature:

With Pseudomonas cepacia lipase; In tert-butyl methyl ether; at 20 ℃; for 120h; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1016/j.tetasy.2009.10.013

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + ethyl 2-hydroxy-3-(4-methoxyphenyl)propanoate (38618-53-0) → (R)-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1206734-18-0) + ethyl (S)-2-hydroxy-3-(4-methoxyphenyl)propanoate (1206734-19-1) + ethyl (R)-2-hydroxy-3-(4-methoxyphenyl)propanoate (33173-51-2) + C12H14O5 (34276-42-1) + ethyl (S)-2-acetoxy-3-(4-methoxyphenyl)propanoate (37504-76-0)

Guidance literature:

vinyl acetate; ethyl 2-hydroxy-3-(4-methoxyphenyl)propanoate; With Pseudomonas cepacia lipase; In tert-butyl methyl ether; at 20 ℃; for 240h; Enzymatic reaction;

With sodium phosphate dibasic dihydrate; water; sodium chloride; sodium hydroxide; bovine α-chymotrypsin; for 72h; pH=7.8; Enzymatic reaction;

With hydrogenchloride; In water; pH=2 - 3; optical yield given as %ee; stereoselective reaction;

DOI:10.1016/j.tetasy.2009.10.013

upstream raw materials:

vinyl acetate

ethyl 2-hydroxy-3-(4-methoxyphenyl)propanoate

Refernces