N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

Base Information

Chemical Name:N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide
CAS No.:1334763-98-2
Molecular Formula:C₂₈H₂₃N₇O
Molecular Weight:473.537
Hs Code.:

Synonyms:N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

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Chemical Property of N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

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Technology Process of N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

There total 4 articles about N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 218288-43-8
2-chloro-N-(3-cyanophenyl)-acetamide

: 1334763-83-5
2,3-dimethyl-6-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-quinoxaline

: 1334763-96-0
N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

: 1334763-98-2
N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

Guidance literature:: With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2011.05.063

Reference yield:

: 614750-85-5
diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate

: 1334763-96-0
N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

: 1334763-98-2
N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol / 16 h / 20 °C

1.2: 1 h

1.3: pH 7 - 8

2.1: acetic acid / N,N-dimethyl-formamide / 2 h / 80 °C

2.2: 4 h / Reflux

3.1: sodium hydride; sodium iodide / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydride; caesium carbonate; acetic acid; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.ejmech.2011.05.063

Reference yield:

: 1334763-82-4
2-(2,3-dimethylquinoxalin-6-yl)-1-(6-methylpyridin-2-yl)ethanone

: 1334763-96-0
N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-3-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

: 1334763-98-2
N-(3-cyanophenyl)-2-[4-(2,3-dimethylquinoxalin-6-yl)-5-(6-methylpyridin-2-yl)-1H-pyrazol-1-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / N,N-dimethyl-formamide / 2 h / 80 °C

1.2: 4 h / Reflux

2.1: sodium hydride; sodium iodide / N,N-dimethyl-formamide / 2 h / 20 °C

With sodium hydride; acetic acid; sodium iodide; In N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.05.063