N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine

Base Information

• Chemical Name: N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine
• CAS No.: 1040239-00-6
• Molecular Formula: C₂₈H₃₉N₅O₅Si
• Molecular Weight: 553.734

Synonyms:N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine

Chemical Property of N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine

Chemical Property:

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Technology Process of N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine

There total 1 articles about N⁽⁶⁾-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chlorodimethyl(1,1,2-trimethylpropyl)silane (67373-56-2) + N-6-benzoyl-2',3'-O-isopropylideneadenosine (39947-04-1) → N(6)-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine (1040239-00-6)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 23 ℃; for 6h;

DOI:10.1002/hlca.200890071

Reference yield: 68.0%

N(6)-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine (1040239-00-6) + methyl iodide (74-88-4) → N6-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-1-methyladenosine (1184837-70-4) + N6-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-N6-methyladenosine (1184837-68-0)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; at 25 ℃;

DOI:10.1002/hlca.200900075

Reference yield:

N(6)-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylideneadenosine (1040239-00-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N6-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-8-formyl-2',3'-O-isopropylideneadenosine

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -70 ℃; for 3.5h;

DOI:10.1002/hlca.200890071

upstream raw materials:

chlorodimethyl(1,1,2-trimethylpropyl)silane

N-6-benzoyl-2',3'-O-isopropylideneadenosine

Downstream raw materials:

N₆-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-1-methyladenosine

N₆-benzoyl-5'-O-[dimethyl(1,1,2-trimethylpropyl)silyl]-2',3'-O-isopropylidene-N₆-methyladenosine

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