{5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

Base Information

• Chemical Name: {5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate
• CAS No.: 943026-54-8
• Molecular Formula: C₁₉H₂₃NO₃S
• Molecular Weight: 345.463
• Mol file: 943026-54-8.mol

Synonyms:{5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

Chemical Property of {5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

There total 7 articles about {5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

sodium tert-butyl thiolate (29364-29-2) → {5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (943026-54-8)

Guidance literature:

(4-[(phenylmethyl)oxy]-5-{[(trifluoromethyl)sulfonyl]oxy}-2-pyridinyl)methyl acetate; With (R)-(+)-2,2’-bis(diphenylphosphino)-1,1’-binaphthalene; palladium diacetate; In toluene; for 0.166667h;

sodium tert-butyl thiolate; In toluene; at 80 ℃; for 7h;

Reference yield:

(4-[(phenylmethyl)oxy]-5-{[(trifluoromethyl)sulfonyl]oxy}-2-pyridinyl)methyl acetate (943026-31-1) + sodium tert-butyl thiolate (29364-29-2) → {5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (943026-54-8)

Guidance literature:

palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl;

Reference yield:

[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate (724788-77-6) → {5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (943026-54-8)

Guidance literature:

Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine

2: triethylsilane

3: triethylamine

4: palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl

With triethylsilane; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl;

upstream raw materials:

sodium tert-butyl thiolate

(4-[(phenylmethyl)oxy]-5-{[(trifluoromethyl)sulfonyl]oxy}-2-pyridinyl)methyl acetate

[5-({[4-(methyloxy)phenyl]methyl}oxy)-4-oxo-1,4-dihydro-2-pyridinyl]methyl acetate

{5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate