2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

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Chemical Name:2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine
CAS No.:1018681-04-3
Molecular Formula:C₂₆H₂₂ClN₅O₃
Molecular Weight:487.945
Hs Code.:

Synonyms:2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

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Chemical Property of 2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

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Technology Process of 2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

There total 6 articles about 2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 657427-36-6
1-[5-(3-chlorophenyl)isoxazol-3-yl]ethanol

: 1018681-00-9
2-benzyloxy-4-(5-methanesulfonyl-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

: 1018681-04-3
2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃;

Reference yield:

: 657424-77-6
ethyl 5-(3-chlorophenyl)isoxazole-3-carboxylate

: 1018681-04-3
2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran; diethyl ether; toluene / 5 h / 0 °C

1.2: 0.5 h / 45 °C

2.1: sodium tetrahydroborate / methanol / 3 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 65 °C

With sodium tetrahydroborate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; N,N-dimethyl-formamide; toluene;

Reference yield:

: C₉H₁₂N₄O₂S

: 1018681-04-3
2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / water / 12 h / 60 °C

2: sodium hydroxide / ethanol; water / 12 h / 20 °C

3: Oxone / methanol; water / 5 h

4: hydrogen bromide / ethanol; acetic acid / 3.5 h / 80 °C

5: silver carbonate / toluene / 72 h / 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 65 °C

With Oxone; sodium hydroxide; hydrogen bromide; caesium carbonate; silver carbonate; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; toluene;