4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one

Base Information

Chemical Name:4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one
CAS No.:1018680-68-6
Molecular Formula:C₁₉H₁₆ClN₅O₃
Molecular Weight:397.821
Hs Code.:

Synonyms:4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one

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Chemical Property of 4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one

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Technology Process of 4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one

There total 13 articles about 4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1018681-04-3
2-benzyloxy-4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-pyridine

: 1018680-68-6
4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol;

Reference yield:

: 26156-51-4
methyl 2-methoxyisonicotinate

: 1018680-68-6
4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: hydrazine / ethanol / 12 h / 75 °C

2: 0.5 h / 60 °C

3: sodium hydroxide / water / 12 h / 60 °C

4: sodium hydroxide / ethanol; water / 12 h / 20 °C

5: Oxone / methanol; water / 5 h

6: hydrogen bromide / ethanol; acetic acid / 3.5 h / 80 °C

7: silver carbonate / toluene / 72 h / 20 °C

8: caesium carbonate / N,N-dimethyl-formamide / 65 °C

9: hydrogen / palladium 10% on activated carbon / ethanol

With Oxone; sodium hydroxide; hydrogen bromide; hydrogen; caesium carbonate; silver carbonate; hydrazine; palladium 10% on activated carbon; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: C₉H₁₂N₄O₂S

: 1018680-68-6
4-(5-{1-[5-(3-chloro-phenyl)-isoxazol-3-yl]-ethoxy}-4-methyl-4H-[1,2,4]triazol-3-yl)-1H-pyridin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / water / 12 h / 60 °C

2: sodium hydroxide / ethanol; water / 12 h / 20 °C

3: Oxone / methanol; water / 5 h

4: hydrogen bromide / ethanol; acetic acid / 3.5 h / 80 °C

5: silver carbonate / toluene / 72 h / 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 65 °C

7: hydrogen / palladium 10% on activated carbon / ethanol

With Oxone; sodium hydroxide; hydrogen bromide; hydrogen; caesium carbonate; silver carbonate; palladium 10% on activated carbon; In methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide; toluene;