4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile

Base Information

Chemical Name:4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile
CAS No.:444808-44-0
Molecular Formula:C₁₈H₁₂Cl₂N₂O
Molecular Weight:343.212
Hs Code.:

4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1<i>H</i>-pyrrol-3-yl}-benzonitrile

Synonyms:4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile

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Chemical Property of 4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile

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Technology Process of 4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile

There total 4 articles about 4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 444808-33-7
4-[4-(2,4-dichloro-benzoyl)-1H-pyrrol-3-yl]-benzonitrile

: 444808-44-0
4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; for 16h; Heating;
DOI:10.1021/jm011087h

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 444808-44-0
4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. NaOH / 0.5 h

2: 44 percent / NaH / dimethylsulfoxide; diethyl ether / 0.5 h / 20 °C

3: 100 percent / NaBH₄ / tetrahydrofuran; H₂O / 16 h / Heating

With sodium hydroxide; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1021/jm011087h

Reference yield:

: 2234-16-4
1-(2,4-dichlorophenyl)ethan-1-one

: 444808-44-0
4-{4-[(2,4-dichloro-phenyl)-hydroxy-methyl]-1H-pyrrol-3-yl}-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / aq. NaOH / 0.5 h

2: 44 percent / NaH / dimethylsulfoxide; diethyl ether / 0.5 h / 20 °C

3: 100 percent / NaBH₄ / tetrahydrofuran; H₂O / 16 h / Heating

With sodium hydroxide; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1021/jm011087h