3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid

Base Information

Chemical Name:3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid
CAS No.:1372589-98-4
Molecular Formula:C₂₂H₁₉N₃O₅S
Molecular Weight:437.476
Hs Code.:

Synonyms:3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid

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Chemical Property of 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid

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Technology Process of 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid

There total 11 articles about 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372589-97-3
methyl 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylate

: 1372589-98-4
3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid

Guidance literature:: methyl 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 18h;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 36692-49-6
Methyl 3,4-diaminobenzoate

: 1372589-98-4
3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; copper / chlorobenzene / 135 °C

2.1: hydrogenchloride / water; methanol / Reflux

3.1: cesium fluoride / DavePhos; palladium diacetate / N,N-dimethyl acetamide; methanol / 18 h / Inert atmosphere; Reflux

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C

4.2: pH 2

With hydrogenchloride; water; copper; potassium carbonate; cesium fluoride; sodium hydroxide; palladium diacetate; DavePhos; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; chlorobenzene; 3.1: Suzuki Coupling;

Reference yield:

: 181765-85-5
methyl 2-iodo 4-chlorobenzoate

: 1372589-98-4
3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; copper / chlorobenzene / 18 h / Reflux

2.1: hydrogenchloride / water; methanol / 18 h / Reflux

3.1: cesium fluoride / DavePhos; palladium diacetate / N,N-dimethyl acetamide; methanol / 18 h / Inert atmosphere; Reflux

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 20 °C

4.2: pH 2

With hydrogenchloride; water; copper; potassium carbonate; cesium fluoride; sodium hydroxide; palladium diacetate; DavePhos; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; chlorobenzene; 3.1: Suzuki Coupling;