4-Chloro-2-iodo-benzoic acid Methyl ester

Base Information

• Chemical Name: 4-Chloro-2-iodo-benzoic acid Methyl ester
• CAS No.: 181765-85-5
• Molecular Formula: C8H6ClIO2
• Molecular Weight: 296.492
• Hs Code.: 2916399090
• Mol file: 181765-85-5.mol

Synonyms:4-CHLORO-2-IODO-BENZOIC ACID METHYL ESTER;

Chemical Property of 4-Chloro-2-iodo-benzoic acid Methyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 2.73120
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-chloro-2-iodobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-iodo-benzoic acid Methyl ester

There total 4 articles about 4-Chloro-2-iodo-benzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 4-chloro-2-iodobenzoic acid (13421-13-1) → methyl 2-iodo 4-chlorobenzoate (181765-85-5)

Guidance literature:

With acetyl chloride; at 65 ℃; Inert atmosphere;

DOI:10.1128/AAC.00670-16

Reference yield: 56.0%

2-amino-4-chloro-benzoic acid methyl ester (5900-58-3) → methyl 2-iodo 4-chlorobenzoate (181765-85-5)

Guidance literature:

2-amino-4-chloro-benzoic acid methyl ester; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.666667h; Inert atmosphere;

With potassium iodide; In water; at 0 - 90 ℃; for 2.16667h; Inert atmosphere;

DOI:10.1039/c7ob02579c

Reference yield:

4-chloro-2-iodobenzoic acid (13421-13-1) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-iodo 4-chlorobenzoate (181765-85-5)

Guidance literature:

With methanol; In diethyl ether; at 20 ℃;

upstream raw materials:

methanol

2-iodo-4-chlorobenzoyl chloride

4-chloro-2-iodobenzoic acid

diazomethyl-trimethyl-silane

Downstream raw materials:

2-<<5-chloro-2-(methoxycarbonyl)phenyl>amino>-3-methylbenzoic acid

methyl 4-chloro-2-[4-(trifluoromethoxy)anilino]benzoate

methyl 4-chloro-2-(2,4-difluoroanilino)benzoate

methyl 4-chloro-2-(2,3,4-trifluoroanilino)benzoic acid

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