3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone

Base Information

• Chemical Name: 3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone
• CAS No.: 740799-11-5
• Molecular Formula: C₁₈H₁₂N₄O
• Molecular Weight: 300.319
• Mol file: 740799-11-5.mol

Synonyms:3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone

Chemical Property of 3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone

Chemical Property:

Purity/Quality:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone

There total 2 articles about 3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ethyl-2-picolinate (2524-52-9,1228273-66-2) + 3-phenyl-[1,2,3]triazolo[1,5-a]pyridine (832-81-5) → 3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone (740799-11-5)

Guidance literature:

With n-butyllithium; In hexane; toluene; at -40 - 20 ℃;

DOI:10.1016/j.tet.2004.05.002

Reference yield: 36.0%

2-Cyanopyridine (100-70-9,1232006-36-8) + 3-phenyl-[1,2,3]triazolo[1,5-a]pyridine (832-81-5) → (3-phenyl-6,8-di(2-pyridyl)-[1,2,3]-triazolo[5′,1′:6,1]pyrido[2,3-d]pyrimidine) + 3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone (740799-11-5)

Guidance literature:

3-phenyl-[1,2,3]triazolo[1,5-a]pyridine; With n-butyllithium; In hexane; toluene; at -40 ℃; for 0.5h; Inert atmosphere;

2-Cyanopyridine; In hexane; toluene; at 20 ℃; for 2h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c5ob00280j

Reference yield: 53.0%

3-phenyl-[1,2,3]triazolo[1,5-a]pyridin-7-yl pyridin-2-yl methanone (740799-11-5) → 2-pyridyl-3-phenyl-[1,2,3]triazolo[1,5-a]pyrid-7-ylmethanol

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1016/j.tet.2004.05.002

upstream raw materials:

ethyl-2-picolinate

3-phenyl-[1,2,3]triazolo[1,5-a]pyridine

2-Cyanopyridine

Downstream raw materials:

3-phenyl-[1,2,3]triazolo[1,5-a]pyridine