2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine

Base Information

• Chemical Name: 2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine
• CAS No.: 101348-93-0
• Molecular Formula: C₂₉H₃₁NO₇
• Molecular Weight: 505.568
• Mol file: 101348-93-0.mol

Synonyms:2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine

Chemical Property of 2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine

There total 1 articles about 2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-benzyl-N,N'-diisopropylisourea (2978-10-1) + 2-(3-(ethoxycarbonyl)propyl)-5-hydroxy-3,4-dicarboxypyridine (101348-91-8) → 2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine (101348-93-0)

Guidance literature:

at 110 ℃; for 2h; Yield given;

DOI:10.1021/ja00268a040

Reference yield:

2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine (101348-93-0) → 3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline (101348-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / benzene / 0.83 h / Heating

2: 41 percent / 2.4N aq. HCl / aq. ethanol / 2 h / Heating

With hydrogenchloride; sodium ethanolate; In ethanol; benzene;

DOI:10.1021/ja00268a040

Reference yield:

2-(3-(ethoxycarbonyl)propyl)-3-(ethoxycarbonyl)-4-((benzyloxy)carbonyl)-5-(benzyloxy)pyridine (101348-93-0) → 3-(benzyloxy)-4-(ethoxycarbonyl)-5,6,7,8-tetrahydro-5-hydroxyquinoline (88889-11-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOEt / benzene / 0.83 h / Heating

2: 41 percent / 2.4N aq. HCl / aq. ethanol / 2 h / Heating

3: 99 percent / NaBH₄, 5percent aq. NaOH / ethanol / 0.17 h / 0 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; sodium ethanolate; In ethanol; benzene;

DOI:10.1021/ja00268a040

upstream raw materials:

O-benzyl-N,N'-diisopropylisourea

2-(3-(ethoxycarbonyl)propyl)-5-hydroxy-3,4-dicarboxypyridine

Downstream raw materials:

3-Benzyloxy-5-oxo-5,6,7,8-tetrahydro-quinoline-4,6-dicarboxylic acid diethyl ester

3-(benzyloxy)-4-(ethoxycarbonyl)-5-oxo-5,6,7,8-tetrahydroquinoline

3-(benzyloxy)-4-(ethoxycarbonyl)-5,6,7,8-tetrahydro-5-hydroxyquinoline

(S)-3-Benzyloxy-5-hydroxy-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester