benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester

Base Information

• Chemical Name: benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester
• CAS No.: 374779-10-9
• Molecular Formula: C₂₀H₂₂N₂O₂
• Molecular Weight: 322.407
• Mol file: 374779-10-9.mol

Synonyms:benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester

Chemical Property of benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester

There total 3 articles about benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-methylindole (603-76-9) + ethyl 2-(benzylimino)acetate (64222-28-2) → benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester (374779-10-9)

Guidance literature:

[Pd(CH₃CN)2(BIPHEP)](SbF₆)2; In 1,2-dichloro-ethane; at 20 ℃; for 18h;

DOI:10.1055/s-2001-16802

Reference yield: 82.0%

1-methylindole (603-76-9) + glyoxylic acid ethyl ester (924-44-7) + benzylamine (100-46-9) → benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester (374779-10-9)

Guidance literature:

at 20 ℃; for 0.666667h;

DOI:10.1055/s-2005-922764

Reference yield:

benzylamine (100-46-9) → benzylamino-(1-methyl-1H-indol-3-yl)-acetic acid ethyl ester (374779-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂SO₄ / CH₂Cl₂ / 1 h

2: 58 kg / Yb(OTf)3 / 18 h

With sodium sulfate; ytterbium(III) triflate; In dichloromethane;

DOI:10.1016/S0040-4039(02)00736-0

upstream raw materials:

1-methylindole

ethyl 2-(benzylimino)acetate

glyoxylic acid ethyl ester

benzylamine