1-(4-Fluorophenyl)-3-(4-methoxyanilino)-1-propanone

Base Information

Chemical Name:1-(4-Fluorophenyl)-3-(4-methoxyanilino)-1-propanone
CAS No.:37155-08-1
Molecular Formula:C₁₆H₁₆FNO₂
Molecular Weight:273.307
Hs Code.:
European Community (EC) Number:646-649-9
Mol file:37155-08-1.mol

Synonyms:37155-08-1;1-(4-fluorophenyl)-3-(4-methoxyanilino)-1-propanone;1-(4-Fluorophenyl)-3-((4-methoxyphenyl)amino)propan-1-one;1-(4-fluorophenyl)-3-(4-methoxyanilino)propan-1-one;1-(4-fluorophenyl)-3-[(4-methoxyphenyl)amino]propan-1-one;SCHEMBL13139118;AKOS005108351;JS-2493;SB82037

Suppliers and Price of 1-(4-Fluorophenyl)-3-(4-methoxyanilino)-1-propanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-3-(4-METHOXYANILINO)-1-PROPANONE 95.00%
5MG
$ 623.82

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-3-(4-METHOXYANILINO)-1-PROPANONE 95.00%
10MG
$ 618.50

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-3-(4-METHOXYANILINO)-1-PROPANONE 95.00%
1MG
$ 586.97

Total 3 raw suppliers

Chemical Property of 1-(4-Fluorophenyl)-3-(4-methoxyanilino)-1-propanone

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:273.11650692
Heavy Atom Count:20
Complexity:295

Purity/Quality:

99% ^*data from raw suppliers

1-(4-FLUOROPHENYL)-3-(4-METHOXYANILINO)-1-PROPANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)NCCC(=O)C2=CC=C(C=C2)F

Technology Process of 1-(4-Fluorophenyl)-3-(4-methoxyanilino)-1-propanone

There total 2 articles about 1-(4-Fluorophenyl)-3-(4-methoxyanilino)-1-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 347-93-3
3-chloro-4'-fluoropropiophenone

: 104-94-9
4-methoxy-aniline

: 37155-08-1
1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one

Guidance literature:: With triethylamine; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/ja0351692

Reference yield:

: 37155-08-1
1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one

Guidance literature:: ω-Dimethylamino-p-fluor-propiophenon*HCl, p-Anisidin, A., kochen (ohne Det. in R.Z);

Reference yield:

: 37155-08-1
1-(4-fluorophenyl)-3-(4-methoxyphenylamino)propan-1-one

: 61869-08-7
paroxetine

Guidance literature:: Multi-step reaction with 9 steps

1: Na₂CO₃ / CH₂Cl₂ / 0.5 h

2: 8.36 g / EtONa / ethanol / 0.5 h / Heating

3: 89 percent / CuCl₂; t-BuONa; (R)-p-tolBINAP / PMHS; tert-amyl alcohol / fluorobenzene / 0.75 h

4: 79 percent / MeOH; NaH / toluene / 4 h / Heating

5: 98 percent / BH₃ / tetrahydrofuran / 18 h / Heating

6: CAN / acetonitrile; H₂O / 0.5 h / 20 °C

7: 268 mg / NaOH / toluene; H₂O / 3 h / 20 °C

8: Cs₂CO₃ / o-xylene / 20 h / 130 °C

9: 99 mg / TFA / CH₂Cl₂ / 0.25 h

With methanol; sodium hydroxide; ammonium cerium(IV) nitrate; borane; sodium ethanolate; sodium hydride; sodium carbonate; caesium carbonate; (R)-tol-BINAP; trifluoroacetic acid; copper dichloride; sodium t-butanolate; tert-Amyl alcohol; In tetrahydrofuran; fluorobenzene; ethanol; dichloromethane; o-xylene; water; toluene; acetonitrile;
DOI:10.1021/ja0351692