(3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester

Base Information

Chemical Name:(3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester
CAS No.:1004791-42-7
Molecular Formula:C₂₇H₂₅F₂NO₄
Molecular Weight:465.497
Hs Code.:

Synonyms:(3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester

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Chemical Property of (3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester

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Technology Process of (3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester

There total 9 articles about (3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₁F₂NO₄

: 75-16-1
methylmagnesium bromide

: 1004791-42-7
(3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: C₂₆H₂₁F₂NO₄; methylmagnesium bromide; In tetrahydrofuran; at -78 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 1004791-41-6
(3R,5S)-3-(3,4-difluorophenyl)-5-hydroxymethylmorpholine-4-carboxylic acid 9H-fluorene-9-ylmethyl ester

: 75-16-1
methylmagnesium bromide

: 1004791-42-7
(3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: (3R,5S)-3-(3,4-difluorophenyl)-5-hydroxymethylmorpholine-4-carboxylic acid 9H-fluorene-9-ylmethyl ester; With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; at -78 ℃; for 0.5h;

With triethylamine; In tetrahydrofuran; at -78 - 20 ℃; for 1.5h;

methylmagnesium bromide; With ammonium chloride; more than 3 stages;

Reference yield:

: 937400-28-7
(5S)-5-[(benzyloxy)methyl]morpholin-3-one

: 1004791-42-7
(3R,5R)-3-(3,4-difluorophenyl)-5-(1-hydroxyethyl)morpholine 4-carboxylic acid 9H-fluoren-9-yl methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dmap / acetonitrile / 3 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 0.5 h / -40 °C

3.1: hydrogenchloride / ethyl acetate / 2.5 h / 20 °C

3.2: 18 h

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 14 h / 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / tetrahydrofuran / 0.58 h / -78 °C

5.2: 1.5 h / -78 - 20 °C

6.1: tetrahydrofuran / 1 h / -78 °C

With hydrogenchloride; oxalyl dichloride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; dmap; In tetrahydrofuran; water; ethyl acetate; acetonitrile;