4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester
CAS No.:847671-88-9
Molecular Formula:C₃₃H₅₀N₂O₁₂SSi
Molecular Weight:726.918
Hs Code.:

4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2<i>H</i>-pyrazine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

There total 7 articles about 4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 847671-87-8
4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-2-but-2-enyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

: 762-72-1
allyl-trimethyl-silane

: 847671-88-9
4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Hoveyda-Grubbs Catalyst II; In dichloromethane; Heating;
DOI:10.1039/b415030a

Reference yield:

: (E)-(S)-2-tert-Butoxycarbonylamino-hex-4-enoic acid

: 847671-88-9
4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 2,2,2-trifluoro-ethanol / 20 - 50 °C

2: t-BuOK; 4 Angstroem molecular sieves / tetrahydrofuran / 0 °C

3: aq. NaBH₄ / tetrahydrofuran

4: TBAF / tetrahydrofuran / 50 °C

5: pyridine

6: 51 percent / Cl₂Ru(-N(Mes)CH₂CH₂(Mes)N-)=CH-C₆H₄-O-i-Pr(o) / CH₂Cl₂ / Heating

With pyridine; sodium tetrahydroborate; 4 A molecular sieve; potassium tert-butylate; tetrabutyl ammonium fluoride; Hoveyda-Grubbs Catalyst II; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; 1: Ugi four-component condensation;
DOI:10.1039/b415030a

Reference yield:

: 2-but-2-enyl-4-[2-hydroxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-hydroxymethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

: 847671-88-9
4-[2-acetoxy-1-(2-methanesulfonyloxy-3,5-dimethoxy-4-methyl-phenyl)-ethyl]-5-acetoxymethyl-3-oxo-2-(4-trimethylsilanyl-but-2-enyl)-3,4-dihydro-2H-pyrazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: 51 percent / Cl₂Ru(-N(Mes)CH₂CH₂(Mes)N-)=CH-C₆H₄-O-i-Pr(o) / CH₂Cl₂ / Heating

With pyridine; Hoveyda-Grubbs Catalyst II; In dichloromethane;
DOI:10.1039/b415030a