Technology Process of (E)-ethyl 4-(1-phenylcyclohexyl)but-2-enoate
There total 5 articles about (E)-ethyl 4-(1-phenylcyclohexyl)but-2-enoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
diethoxyphosphoryl-acetic acid ethyl ester;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
(1-phenyl-cyclohexyl)-acetaldehyde;
at 0 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hexamethyldisilazane / 1,2-dimethoxyethane / 0.33 h / Cooling with ice
1.2: 0.33 h / 20 °C
1.3: 2 h / 20 °C
2.1: potassium hydroxide / ethylene glycol / 3.5 h / 100 °C / Reflux
3.1: 4 h / 200 °C
4.1: sodium periodate / osmium(VIII) oxide / water; tert-butyl alcohol; tetrahydrofuran / 18 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
5.2: 2 h / 0 °C
With
sodium periodate; potassium tert-butylate; sodium hexamethyldisilazane; potassium hydroxide;
osmium(VIII) oxide;
In
tetrahydrofuran; 1,2-dimethoxyethane; water; ethylene glycol; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hydroxide / ethylene glycol / 3.5 h / 100 °C / Reflux
2.1: 4 h / 200 °C
3.1: sodium periodate / osmium(VIII) oxide / water; tert-butyl alcohol; tetrahydrofuran / 18 h / 20 °C
4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
4.2: 2 h / 0 °C
With
sodium periodate; potassium tert-butylate; potassium hydroxide;
osmium(VIII) oxide;
In
tetrahydrofuran; water; ethylene glycol; tert-butyl alcohol;
