N-benzyl-2-bromo-5-methylbenzamide

Base Information

• Chemical Name: N-benzyl-2-bromo-5-methylbenzamide
• CAS No.: 1401880-57-6
• Molecular Formula: C₁₅H₁₄BrNO
• Molecular Weight: 304.186
• Mol file: 1401880-57-6.mol

Synonyms:N-benzyl-2-bromo-5-methylbenzamide

Chemical Property of N-benzyl-2-bromo-5-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-benzyl-2-bromo-5-methylbenzamide

There total 1 articles about N-benzyl-2-bromo-5-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-bromo-5-methylbenzoic acid (6967-82-4) + benzylamine (100-46-9) → N-benzyl-2-bromo-5-methylbenzamide (1401880-57-6)

Guidance literature:

2-bromo-5-methylbenzoic acid; With triethylamine; isobutyl chloroformate; In dichloromethane; for 0.25h; Inert atmosphere; Schlenk technique;

benzylamine; In dichloromethane; at 0 ℃;

DOI:10.1002/ejoc.201501170

Reference yield: 79.0%

N-benzyl-2-bromo-5-methylbenzamide (1401880-57-6) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 5-benzyl-8-methylphenanthridin-6(5H)-one (1401880-77-0)

Guidance literature:

With palladium diacetate; sodium carbonate; cesium fluoride; bis-diphenylphosphinomethane; In toluene; acetonitrile; at 20 - 110 ℃;

DOI:10.1021/jo3016192

Reference yield: 47.0%

N-benzyl-2-bromo-5-methylbenzamide (1401880-57-6) → C30H26N2O2

Guidance literature:

With palladium(II) trifluoroacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In 1,4-dioxane; at 100 ℃; for 12h; regioselective reaction; Sealed tube;

DOI:10.1016/j.mcat.2021.111766

upstream raw materials:

2-bromo-5-methylbenzoic acid

benzylamine

Downstream raw materials:

5-benzyl-8-methylphenanthridin-6(5H)-one