2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate
CAS No.:847153-45-1
Molecular Formula:C₃₆H₃₇NO₄SSi
Molecular Weight:607.846
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate

Suppliers and Price of 2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate

There total 6 articles about 2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 847153-44-0
(4S)-4-(1-methylethyl)-5,5-diphenyl-3-{(2S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoyl}oxazolidin-2-one

: 847153-45-1
2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate

Guidance literature:: 2-(Trimethylsilyl)ethanol; With n-butyllithium; In tetrahydrofuran; hexane; at -30 ℃; for 0.25h;

(4S)-4-(1-methylethyl)-5,5-diphenyl-3-{(2S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoyl}oxazolidin-2-one; In tetrahydrofuran; hexane; at -40 - -30 ℃; for 5.5h;
DOI:10.1002/hlca.200490280

Reference yield:

: 85-44-9
phthalic anhydride

: 847153-45-1
2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 94 percent / 2 h / 150 °C

2.1: 100 percent / (COCl)2 / CH₂Cl₂; dioxane / 20 °C

3.1: BuLi / tetrahydrofuran; hexane / cooling

3.2: 86 percent / tetrahydrofuran; hexane / 48 h / 20 °C

4.1: NEt₃; TiCl₄ / CH₂Cl₂ / 0.5 h / -10 °C

4.2: 89 percent / TiCl₄ / CH₂Cl₂ / -10 - 0 °C

5.1: 71 percent / Bu₃P; azidodicarboxylic dipiperidide / tetrahydrofuran / 1 h / 20 °C

6.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -30 °C

6.2: 55 percent / tetrahydrofuran; hexane / 5.5 h / -40 - -30 °C

With n-butyllithium; oxalyl dichloride; tributylphosphine; azidodicarboxylic dipiperidide; titanium tetrachloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1002/hlca.200490280

Reference yield:

: 3339-73-9
3-phthalimidopropanoic acid

: 847153-45-1
2-(trimethylsilyl)ethyl (S)-2-(phthalimidomethyl)-3-[(triphenylmethyl)sulfanyl]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / (COCl)2 / CH₂Cl₂; dioxane / 20 °C

2.1: BuLi / tetrahydrofuran; hexane / cooling

2.2: 86 percent / tetrahydrofuran; hexane / 48 h / 20 °C

3.1: NEt₃; TiCl₄ / CH₂Cl₂ / 0.5 h / -10 °C

3.2: 89 percent / TiCl₄ / CH₂Cl₂ / -10 - 0 °C

4.1: 71 percent / Bu₃P; azidodicarboxylic dipiperidide / tetrahydrofuran / 1 h / 20 °C

5.1: BuLi / tetrahydrofuran; hexane / 0.25 h / -30 °C

5.2: 55 percent / tetrahydrofuran; hexane / 5.5 h / -40 - -30 °C

With n-butyllithium; oxalyl dichloride; tributylphosphine; azidodicarboxylic dipiperidide; titanium tetrachloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1002/hlca.200490280