(2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane

Base Information

Chemical Name:(2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane
CAS No.:96481-79-7
Molecular Formula:C₁₆H₂₄O₂S
Molecular Weight:280.431
Hs Code.:

Synonyms:(2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane

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Technology Process of (2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane

There total 6 articles about (2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 96481-78-6
(2S,4R)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)pentan-1-ol

: 882-33-7
diphenyldisulfane

: 96481-79-7
(2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane

Guidance literature:: With pyridine; tributylphosphine; for 24h; Ambient temperature;
DOI:10.1021/ja00275a055

Reference yield:

: 96481-75-3
(2S,4R)-methyl 2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentanoate

: 96481-79-7
(2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / LiAlH₄ / diethyl ether / 12 h / Ambient temperature

2: 91 percent / tri-n-butylphosphine (n-Bu₃P), pyridine / 24 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; tributylphosphine; In diethyl ether;
DOI:10.1021/ja00275a055

Reference yield:

: 102849-16-1
(2S,4R)-4-Chlorocarbonyl-2-methyl-pentanoic acid methyl ester

: 96481-79-7
(2S,4R)-1-(phenylthio)-2-methyl-4-(2'-methyl-1',3'-dioxolan-2'-yl)-pentane

Guidance literature:: Multi-step reaction with 4 steps

1: CuI / tetrahydrofuran / 0.5 h / -78 °C

2: 86 percent / pyridinium tosylate (PPTS) / benzene / 6 h / Heating

3: 98 percent / LiAlH₄ / diethyl ether / 12 h / Ambient temperature

4: 91 percent / tri-n-butylphosphine (n-Bu₃P), pyridine / 24 h / Ambient temperature

With pyridine; copper(l) iodide; lithium aluminium tetrahydride; tributylphosphine; pyridinium p-toluenesulfonate; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1021/ja00275a055