2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide

Base Information

Chemical Name:2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide
CAS No.:1345880-51-4
Molecular Formula:C₂₅H₂₉NO₅
Molecular Weight:423.509
Hs Code.:

Synonyms:2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide

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Chemical Property of 2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide

Chemical Property:

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Technology Process of 2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide

There total 8 articles about 2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.7%

: 5395-67-5
2‐bromo‐N‐propylacetamide

: 1345882-27-0
4-(3-(cyclopropylmethoxy)-2-hydroxy-4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one

: 1345880-51-4
2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 16h;

Reference yield:

: 15115-60-3
4-bromo-2,3-dihydroinden-1-one

: 1345880-51-4
2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4 h / 80 °C / Inert atmosphere

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

3: hydrogenchloride; water / methanol / 2 h / 20 °C

4: potassium carbonate / acetonitrile / 16 h / 70 °C

With hydrogenchloride; water; potassium acetate; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 934-00-9
3-methocycatechol

: 1345880-51-4
2-[2-cyclopropylmethoxy-3-methoxy-6-(1-oxoindan-4-yl)phenoxy]-N-propylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / tetrachloromethane / 2 h / 20 °C

2: potassium carbonate / acetone / 2 h / 20 °C

3: potassium carbonate / acetonitrile / 1 h / 0 - 20 °C

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

5: hydrogenchloride; water / methanol / 2 h / 20 °C

6: potassium carbonate / acetonitrile / 16 h / 70 °C

With hydrogenchloride; N-Bromosuccinimide; water; potassium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; tetrachloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;