N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide

Base Information

Chemical Name:N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide
CAS No.:117523-51-0
Molecular Formula:C₂₂H₂₃ClN₄O₂
Molecular Weight:410.903
Hs Code.:

Synonyms:N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide

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Chemical Property of N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide

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Technology Process of N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide

There total 4 articles about N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 26214-65-3
furan-3-carbonyl chloride

: 118142-53-3
1-phenethyl-4-piperidine

: 117523-51-0
N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide

Guidance literature:: With triethylamine; In chloroform; for 0.5h; Ambient temperature;
DOI:10.1021/jm00123a028

Reference yield:

: 488-93-7
3-Furoic acid

: 117523-51-0
N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 44 h / Ambient temperature

2: 55 percent / Et₃N / CHCl₃ / 0.5 h / Ambient temperature

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; chloroform;
DOI:10.1021/jm00123a028

Reference yield:

: 79278-71-0
1-phenethylpiperidin-4-one oxime

: 117523-51-0
N-(4-chloro-pyrimidin-6-yl)-N-[1-(2-phenylethyl)-4-piperidyl]-3-furamide

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran / Heating

2: 77 percent / triethylamine / ethanol / 2 h / Heating

3: 55 percent / Et₃N / CHCl₃ / 0.5 h / Ambient temperature

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00123a028