N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Base Information

• Chemical Name: N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
• CAS No.: 420122-78-7
• Molecular Formula: C₂₉H₄₆N₆O₄Si₂
• Molecular Weight: 598.893

Synonyms:N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Chemical Property of N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

There total 16 articles about N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N6-benzoyl-3'-(tert-butyloxycarbonylamino)-2',5'-bis-O-(tert-butyldimethylsilyl)-3'-deoxyadenosine (420122-77-6) → N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (420122-78-7)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 0 ℃; for 0.75h;

DOI:10.1016/S0040-4020(01)01185-1

Reference yield: 81.2%

C23H32N6O4Si + tert-butyldimethylsilyl chloride (18162-48-6) → N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (420122-78-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 78.0%

N-(9-((2R,3R,4R,5S)-3-((tert-Butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(dibenzylamino)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide → N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide (420122-78-7)

Guidance literature:

With hydrogen; palladium dichloride; zinc dibromide; In N,N-dimethyl-formamide; at 0 ℃; for 6h; Large scale;

upstream raw materials:

N⁶-benzoyl-3'-(tert-butyloxycarbonylamino)-2',5'-bis-O-(tert-butyldimethylsilyl)-3'-deoxyadenosine

2',5'-bis-O-(tert-butyldimethylsilyl)adenosine

9-(2,5-di-O-tert-butyldimethylsilyl-β-D-erythro-pentofuran-3-ulosyl)adenosine

2'-O-(tert-butyldimethylsilyl)-3'-(hydroxyamino)-3'-deoxyadenosine

Downstream raw materials:

N⁶-benzoyl-2′,5′-bis-O-(tert-butyldimethylsilyl)-3′-(S)-methylcarbamate-3′-deoxyadenosine

N⁶-benzoyl-2′-O-(tert-butyldimethylsilyl)-3′-(N-tert-butyloxycarbonyl-L-alanine)amido-3′-deoxyadenosine

N⁶-benzoyl-2',5'-bis-O-(tert-butyldimethylsilyl)-3'-[(N-(9-fluorenylmethyloxycarbonyl)thiocarbamoyl)amino]-3'-deoxyadenosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 420122-78-7 N-(9-((2R,3R,4R,5S)-4-amino-3-((tert-butyldimethylsilyl)oxy)-5-(tert-butyldimethylsilyloxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send