Oxirane, 2-ethynyl-3-phenyl-

Base Information

• Chemical Name: Oxirane, 2-ethynyl-3-phenyl-
• CAS No.: 221129-39-1
• Molecular Formula: C10H8 O
• Molecular Weight: 0
• Mol file: 221129-39-1.mol

Synonyms:Oxirane, 2-ethynyl-3-phenyl-

Chemical Property of Oxirane, 2-ethynyl-3-phenyl-

Chemical Property:

• PSA: 12.53000
• LogP: 1.75970

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxirane, 2-ethynyl-3-phenyl-

There total 4 articles about Oxirane, 2-ethynyl-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-phenyl-2-phenylsulfanyl-but-3-yn-1-ol → 2-ethynyl-3-phenyl-oxirane (221129-39-1)

Guidance literature:

With trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1016/S0040-4039(99)01152-1

Reference yield:

benzaldehyde (100-52-7) → 2-ethynyl-3-phenyl-oxirane (221129-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / LDA, zinc bromide / tetrahydrofuran / -78 °C

2: potassium fluoride / dimethylformamide

3: aq. NaOH

With potassium fluoride; sodium hydroxide; zinc dibromide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(98)80023-3

Reference yield:

3-chloro-4-phenyl-1-(trimethylsilyl)but-1-yn-4-ol → 2-ethynyl-3-phenyl-oxirane (221129-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium fluoride / dimethylformamide

2: aq. NaOH

With potassium fluoride; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(98)80023-3

upstream raw materials:

benzaldehyde

Downstream raw materials:

(±)-4-[dimethyl(phenyl)silyl]-1-phenylbut-3-yn-1-ol

(±)-1-phenyloct-3-yn-1-ol

1-phenylbuta-2,3-dien-1-one

Refernces

• 1、 Engstrom, Gregory,Morelli, Meisha,Palomo, Carolyn,Mitzel, Thomas. "Use of α-chlorosulfides in indium promoted C-C couplings: Easy entry into the stereoselective formation of epoxy alkynes". . p. 5967 - 5970. Retrieved 2007/10/03.