N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide

Base Information

Chemical Name:N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide
CAS No.:1445992-70-0
Molecular Formula:C₂₈H₂₅N₃O₆S₂
Molecular Weight:563.655
Hs Code.:

Synonyms:N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide

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Chemical Property of N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide

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Technology Process of N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide

There total 11 articles about N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1445993-89-4
6-methyl-1-[(4-methylphenyl)sulfonyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

: 1445994-12-6
N-(3-bromo-4-phenoxyphenyl)methanesulfonamide

: 1445992-70-0
N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In 1,4-dioxane; water; at 60 ℃; for 2h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.jmedchem.7b00746

Reference yield:

: 701-45-1
2-bromo-1-fluoro-4-nitrobenzene

: 1445992-70-0
N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dimethyl sulfoxide / 1 h / 110 °C

2.1: ammonium chloride; iron / water; ethanol; tetrahydrofuran / 2 h / 100 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

3.2: 1 h / 70 °C

4.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 1,4-dioxane; water / 3 h / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; caesium carbonate; triethylamine; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 108-95-2,27073-41-2
phenol

: 1445992-70-0
N-(3-{6-methyl-1-[(4-methylphenyl)sulfonyl]-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl}-4-phenoxyphenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dimethyl sulfoxide / 1 h / 110 °C

2.1: ammonium chloride; iron / water; ethanol; tetrahydrofuran / 2 h / 100 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

3.2: 1 h / 70 °C

4.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / 1,4-dioxane; water / 3 h / Inert atmosphere

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; ammonium chloride; caesium carbonate; triethylamine; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; dimethyl sulfoxide;