(2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester

Base Information

Chemical Name:(2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester
CAS No.:88559-53-9
Molecular Formula:C₃₆H₄₉O₈PSi
Molecular Weight:668.84
Hs Code.:

Synonyms:(2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester

Suppliers and Price of (2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester

There total 8 articles about (2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 88559-52-8,88588-69-6
(2-{(4S,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-hydroxy-ethyl)-phosphonic acid dimethyl ester

: 88559-53-9
(2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester

Guidance literature:: With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In dichloromethane; T,time;
DOI:10.1016/S0040-4039(00)88259-3

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 88559-53-9
(2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

2: 83 percent / n-butyllithium / tetrahydrofuran / 1 h / 0 °C

3: 67 percent / pyridinium chlorochromate, 4A molecular sieves / CH₂Cl₂ / 18 h / 25 °C

4: 64 percent / tetrahydrofuran / 0.5 h / -78 °C

5: 81 percent / DMSO,(CF₃CO)2O,Et₃N / CH₂Cl₂ / T,time

With 2,6-dimethylpyridine; n-butyllithium; 4 A molecular sieve; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)88259-3

Reference yield:

: 54503-64-9,54503-65-0
2,3-O-isopropylidene-5-O-trityl-D-ribofuranose

: 88559-53-9
(2-{(4R,5S)-5-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-2-trityloxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-2-oxo-ethyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / sodium borohydride / ethanol / 1 h / 0 °C

2: 87 percent / pyridine / 1 h / 25 °C

3: 84 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / 0 °C

4: 83 percent / n-butyllithium / tetrahydrofuran / 1 h / 0 °C

5: 67 percent / pyridinium chlorochromate, 4A molecular sieves / CH₂Cl₂ / 18 h / 25 °C

6: 64 percent / tetrahydrofuran / 0.5 h / -78 °C

7: 81 percent / DMSO,(CF₃CO)2O,Et₃N / CH₂Cl₂ / T,time

With pyridine; 2,6-dimethylpyridine; sodium tetrahydroborate; n-butyllithium; 4 A molecular sieve; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; trifluoroacetic anhydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(00)88259-3