Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate

Base Information

Chemical Name:Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate
CAS No.:76447-27-3
Molecular Formula:C₂₀H₂₄N₂O₇
Molecular Weight:404.42
Hs Code.:

Synonyms:Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate

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Chemical Property of Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate

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Technology Process of Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate

There total 8 articles about Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 76447-26-2
Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxybenzoyl)-(E)-4-(1-propenyl)pyrrole-2-carboxylate

: 76447-27-3
Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate

Guidance literature:: With hydrogen; poly(acrylonitrile-co-stryrene); lead acetate; calcium carbonate; In toluene; for 7h; under 760 Torr; Ambient temperature;
DOI:10.1021/jo00320a028

Reference yield:

: 7126-57-0
ethyl 4-formylpyrrole-2-carboxylate

: 76447-27-3
Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg / 1.) ether 2.) ether-THF, 0 deg C, 2.5 h

2: dimethylsulfoxide / 2.5 h / 160 °C

3: 1.) NaH, / 1.) THF, 40 deg C, 30 min, 2.) room temp., 1.25 h

4: 87 percent / H₂ / 5percent Pd/CaCO₃/Pb(OAc)2 / toluene / 7 h / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; magnesium; poly(acrylonitrile-co-stryrene); lead acetate; calcium carbonate; In dimethyl sulfoxide; toluene;
DOI:10.1021/jo00320a028

Reference yield:

: 60441-79-4
methyl 3,5-dimethoxy-4-methylbenzoate

: 76447-27-3
Ethyl 1-(2-Nitro-4-methyl-3,5-dimethoxy-benzoyl)-4-propylpyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / cupric nitrate / acetic anhydride / 1.5 h

2: 70 percent / potassium hydroxide / methanol; H₂O / 1.5 h / Heating

3: thionyl chloride, pyridine / CHCl₃ / 0.17 h / Heating

4: 1.) NaH, / 1.) THF, 40 deg C, 30 min, 2.) room temp., 1.25 h

5: 87 percent / H₂ / 5percent Pd/CaCO₃/Pb(OAc)2 / toluene / 7 h / 760 Torr / Ambient temperature

With pyridine; potassium hydroxide; thionyl chloride; hydrogen; sodium hydride; copper(II) nitrate; poly(acrylonitrile-co-stryrene); lead acetate; calcium carbonate; In methanol; chloroform; water; acetic anhydride; toluene;
DOI:10.1021/jo00320a028