60441-79-4

Usage

InChI:InChI=1/C11H14O4/c1-7-9(13-2)5-8(11(12)15-4)6-10(7)14-3/h5-6H,1-4H3

Upstream product

• 186581-53-3 diazomethane 
• 75238-29-8 3,5-dihydroxy-4-methylbenzoic acid methyl ester 
• 61040-81-1 4-methyl-3,5-dimethoxybenzoic acid 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 74896-66-5 Methyl 3,5-Dibromo-4-methylbenzoate 
• 124-41-4 sodium methylate 
• 7577-74-4 6-acetoxy-6-methylcyclohexa-2,4-dienone 
• 608-25-3 2-methylbenzene-1,3-diol 
• 6971-52-4 3-methoxy-2-methylphenol 
• 21390-25-0 1,3-dimethoxy-2,5-dimethylbenzene 
• 874514-68-8 (4-carboxy-2,6-dimethoxy-phenyl)-acetic acid 
• 28026-96-2 3,5-dihydroxy-4-methylbenzoic acid 

Downstream Products

• 104447-91-8 methyl 4-bromomethyl-3,5-dimethoxybenzoate 
• 110451-88-2 2-iodo-3,5-dimethoxy-4-methylbenzyl alcohol 
• 110452-01-2 6-hydroxymethyl-2,4-dimethoxy-3-methylbenzonitrile 
• 76447-17-1 Methyl 4-Methyl-3,5-dimethoxy-2-nitrobenzoate 
• 60441-80-7 2-Bromo-3,5-dimethoxy-4-methyl-benzoic acid methyl ester 
• 1456890-81-5 (+)-peniciketal B 
• 1456890-80-4 (+)-peniciketal A 
• 114972-98-4 3-bromo-2,6-dimethoxy-4-methoxymethyltoluene 

Relevant academic research and scientific papers

Preparation method of 3,5-dimethoxy-4-methyl benzoic acid

The invention discloses a preparation method of 3,5-dimethoxy-4-methyl benzoic acid, which comprises the following steps: adding methyl 4-methyl benzoate in a first organic solvent, adding bromine, and carrying out bromination reaction to obtain methyl 3,

COMPOUNDS WITH 7-MEMBER CYCLE AND THE PHARMACEUTICAL USE THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLISM SYNDROME

The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

Pyrrolobenzodiazepines

Compounds of the formulae Ia and Ib: wherein:A is CH2, or a single bond;R2 is selected from: R, OH, OR, CO2H, CO2R, COH, COR, SO2R, CN;R6, R7 and R9 are independently selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn;and R8 is selected from H, R, OH, OR, halo, amino, NHR, nitro, Me3Sn, where R is as defined above, or the compound is a dimer with each monomer being the same or different and being of formula Ia or Ib, where the R8 groups of the monomers form together a bridge having the formula -X-R'-X- linking the monomers, where R' is an alkylene chain containing from 3 to 12 carbon atoms, which chain may be interrupted by one or more hetero-atoms and/or aromatic rings and may contain one or more carbon-carbon double or triple bonds, and each X is independently selected from O, S, or N; except that in a compound of formula Ia when A is a single bond, then R2 is not CH=CH(CONH2) or CH=CH(CONMe2). Other related compounds are also disclosed.

Approaches to the fully functionalized DEF ring system of ristocetin A via highly selective ruthenium-promoted SNAr reaction

Ruthenium-promoted intramolecular SNAr reaction has allowed the construction of the fully functionalized 16-membered DEF macrocycle 4 of ristocetin A that incorporates the required arylglycine and arylserine residues as the F and E ring, respectively.

Molecular Recognition of Amines and Amino Esters by Zinc Porphyrin Receptors: Binding Mechanisms and Solvent Effects

Zinc porphyrin receptors bearing 12 ester groups in the meso phenyl groups (1-3) were prepared, and binding of amines and α-amino esters was studied with emphasis on the binding mechanisms. The X-ray crystallographic analysis of 5,10,15,20-tetrakis(2,6-bis(carbomethoxymethoxy)-4-carbomethoxyphenyl)porphyrin (free base of 1) showed that the receptor has a binding pocket above the porphyrin plane. UV-visible titration experiments revealed that the zinc porphyrin receptors bound amines and α-amino esters with binding constants (Ka) ranging from 0.5 to 52 700 M-1 in CH2Cl2 at 25°C. The ester functional groups of 1 assisted the binding of aromatic α-amino esters (Ka = 8 000-23 000 M-1 in CH2Cl2 at 25°C) and inhibited the binding of bulky aliphatic α-amino esters (Ka = 460 M-1 for Leu-OMe in CH2Cl2 at 25°C), ndicating that CH-π type interactions and steric repulsions control the selectivity. The binding of amines and α-amino esters was tight both in a nonpolar solvent (CH2Cl2) and in a polar solvent (water) but loose in a solvent of intermediate polarity (H2O-MeOH (1:1)), demonstrating that two competitive driving forces are operating: (1) attractive electrostatic forces between host and guest such as coordination of the amino group to the zinc atom, and (2) entropic forces stemming from desolvation as well as enthalpic forces due to the host-guest dispersion forces. The former forces drive the binding in CH2Cl2 while the latter forces drive the binding in water. The enthalpy changes in the binding in CH2Cl2 and those in water range from -50 to -30 kJ mol-1 and from -35 to 0 kJ mol-1, respectively. The entropy changes in CH2Cl2 and those in water range from -120 to -60 J K-1 mol-1 and from -50 to +60 J K-1 mol-1, respectively. Thus the binding in CH2Cl2 is characterized by large negative enthalpy changes, while that in water by less negative entropy changes. These thermodynamic parameters also indicate that host-guest polar interactions (enthalpic forces) drive the binding in CH2Cl2 while both host-guest dispersion interactions (an enthalpic force) and desolvation (an entropic force) drive the binding in water. Enthalpy-entropy compensation observed for the binding in water indicates that the binding of amines and amino esters in water by zinc porphyrins is associated with conformational changes as well as a high degree of dehydration. In CH2Cl2, no clear compensation was observed, consistent with the mechanism that neither desolvation processes nor conformational changes contribute significantly to the binding energetics.

Synthesis of isochromans and their derivatives

Isochromans and their derivatives have been chemically synthesized. These compounds possess significant phytotoxic activity which may be used as a biodegradable contact herbicide. The synthetic method allows for economic production of these herbicides.

Syntheses of 3,7-Dimethyl-8-hydroxy-6-methoxyisochroman, the 3,7-Dimethyl-6-hydroxy-8-methoxy Isomer, and Their Ester and Ether Derivatives: Plant Growth Regulatory Activity

A systematic invesitgation of ester and ether derivatives of 3,7-dimethyl-8-hydroxy-6-methoxyisochroman and 3,7-dimethyl-6-hydroxy-8-methoxyisochroman has established that all of the derivatives synthesized exhibited activity in the wheat coleoptile assay, with several of the compounds being more active than the parent systems.