8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran

Base Information

Chemical Name:8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran
CAS No.:342906-16-5
Molecular Formula:C₃₂H₃₅NO₄Si
Molecular Weight:525.72
Hs Code.:

Synonyms:8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran

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Chemical Property of 8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran

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Technology Process of 8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran

There total 4 articles about 8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 100-39-0
benzyl bromide

: 181427-91-8
8-t-butyldimethylsilyloxy-3-cyanomethyl-6-methoxy-1-oxo-1H-2-benzopyran

: 342906-16-5
8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran

Guidance literature:: With sodium hydride; In tetrahydrofuran; at -30 ℃;
DOI:10.7164/antibiotics.54.285

Reference yield:

: 132971-59-6
8-hydroxy-3-hydroxymethyl-6-methoxyisocoumarin

: 342906-16-5
8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / CCl₄; PPh₃ / tetrahydrofuran / 2 h / Heating

2: 84 percent / dimethylsulfoxide / 1 h / 20 °C

3: 75 percent / imidazole / dimethylformamide / 2 h / 0 °C

4: 86 percent / NaH / tetrahydrofuran / -30 °C

With 1H-imidazole; tetrachloromethane; sodium hydride; triphenylphosphine; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.54.285

Reference yield:

: 149457-12-5
3-chloromethyl-8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran

: 342906-16-5
8-t-butyldimethylsilyloxy-3-(1-benzyl-1-cyano-2-phenyl)ethyl-6-methoxy-1-oxo-1H-2-benzopyran

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / dimethylsulfoxide / 1 h / 20 °C

2: 75 percent / imidazole / dimethylformamide / 2 h / 0 °C

3: 86 percent / NaH / tetrahydrofuran / -30 °C

With 1H-imidazole; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.7164/antibiotics.54.285