2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide

Base Information

Chemical Name:2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide
CAS No.:1335213-17-6
Molecular Formula:C₂₆H₃₄ClN₃O
Molecular Weight:440.028
Hs Code.:

Synonyms:2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide

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Chemical Property of 2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide

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Technology Process of 2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide

There total 7 articles about 2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1335213-34-7
[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid pentafluorophenyl ester

: 108-91-8,157973-60-9
cyclohexylamine

: 1335213-17-6
2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 30h; Inert atmosphere;

Reference yield:

: 409099-31-6
3-benzotriazol-1-yl-2-cyclohexyl-3-oxo-propionic acid ethyl ester

: 1335213-17-6
2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 2.42 h / -78 °C / Inert atmosphere

1.2: 14 h / 20 °C / Inert atmosphere

2.1: ethanol / 6 h / Reflux

3.1: sodium hydroxide; water / methanol / 14 h / 20 °C / Cooling with ice

4.1: pyridine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5.1: dmap / N,N-dimethyl-formamide / 30 h / 20 °C / Inert atmosphere

With pyridine; dmap; water; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; n-heptane; ethylbenzene; N,N-dimethyl-formamide;

Reference yield:

: chlorocarbonyl-cyclohexyl-acetic acid ethyl ester

: 1335213-17-6
2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 2.42 h / -78 °C / Inert atmosphere

2.2: 14 h / 20 °C / Inert atmosphere

3.1: ethanol / 6 h / Reflux

4.1: sodium hydroxide; water / methanol / 14 h / 20 °C / Cooling with ice

5.1: pyridine / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

6.1: dmap / N,N-dimethyl-formamide / 30 h / 20 °C / Inert atmosphere

With pyridine; dmap; water; triethylamine; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide;