[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester

Base Information

• Chemical Name: [2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester
• CAS No.: 1335213-31-4
• Molecular Formula: C₂₂H₂₇ClN₂O₂
• Molecular Weight: 386.922
• Mol file: 1335213-31-4.mol

Synonyms:[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester

Chemical Property of [2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester

There total 4 articles about [2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-cyclohexyl-3-oxo-3-(2-oxo-cyclopentyl)-propionic acid ethyl ester (1335213-30-3) + N-4-chlorophenylhydrazine (1073-69-4) → [2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester (1335213-31-4)

Guidance literature:

In ethanol; for 6h; Reflux;

Reference yield:

3-benzotriazol-1-yl-2-cyclohexyl-3-oxo-propionic acid ethyl ester (409099-31-6) → [2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester (1335213-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 2.42 h / -78 °C / Inert atmosphere

1.2: 14 h / 20 °C / Inert atmosphere

2.1: ethanol / 6 h / Reflux

With lithium diisopropyl amide; In tetrahydrofuran; ethanol; n-heptane; ethylbenzene;

Reference yield:

chlorocarbonyl-cyclohexyl-acetic acid ethyl ester → [2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid ethyl ester (1335213-31-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 14 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 2.42 h / -78 °C / Inert atmosphere

2.2: 14 h / 20 °C / Inert atmosphere

3.1: ethanol / 6 h / Reflux

With triethylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; n-heptane; dichloromethane; ethylbenzene;

upstream raw materials:

2-cyclohexyl-3-oxo-3-(2-oxo-cyclopentyl)-propionic acid ethyl ester

N-4-chlorophenylhydrazine

3-benzotriazol-1-yl-2-cyclohexyl-3-oxo-propionic acid ethyl ester

Ethyl hydrogen 2-cyclohexylpropanedioate

Downstream raw materials:

4-{2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethoxy}-3,5-dimethyl-benzoic acid methyl ester

2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2,N-dicyclohexyl-acetamide

2-[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-2-cyclohexyl-ethanol

[2-(4-chloro-phenyl)-2,4,5,6-tetrahydro-cyclopentapyrazol-3-yl]-cyclohexyl-acetic acid