methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Base Information

Chemical Name:methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate
CAS No.:122223-38-5
Molecular Formula:C₂₂H₃₀FNO₄
Molecular Weight:391.483
Hs Code.:

Synonyms:methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

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Chemical Property of methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

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Technology Process of methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

There total 14 articles about methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 122235-59-0
methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

: 6-{2-[4-(4-Fluoro-phenyl)-1-isopropyl-2-methyl-1H-pyrrol-3-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one

: 122223-38-5
methyl 3(RS),5(RS)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

: 122223-38-5
methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 0.333333h; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jm00163a011

Reference yield: 8.0%

: 122235-59-0
methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

: 6-{2-[4-(4-Fluoro-phenyl)-1-isopropyl-2-methyl-1H-pyrrol-3-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one

: 122223-38-5
methyl 3(RS),5(RS)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

: 122223-38-5
methyl 3(RS),5(SR)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 0.333333h; Title compound not separated from byproducts; Ambient temperature;
DOI:10.1021/jm00163a011

Reference yield:

: 5153-69-5,706-08-1
4-fluoro-β-nitrostyrene

: 122223-38-5
methyl 3(RS),5(RS)-dihydroxy-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>heptanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 22.0 g / sodium methanolate / methanol / 2.25 h / 0 °C

2: 7.3 g / methanol / 1.) 40 deg C, 2 h, 2.) 50 deg C, 5 h

3: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h

4: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

7: 1.) 1 M triethylborane, 2.) sodium borohydride / 1.) THF, 20 deg C, 140 min, 2.) -75 deg C, 12 h

8: H₂, triethylamine / 10percent Pd/C / methanol / 0.33 h / Ambient temperature

With manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; triethyl borane; hydrogen; sodium methylate; triethylamine; palladium on activated charcoal; In methanol; diethyl ether;
DOI:10.1021/jm00163a011