1,4-Difluoro-2,3-dimethoxybenzene

Base Information

• Chemical Name: 1,4-Difluoro-2,3-dimethoxybenzene
• CAS No.: 75626-18-5
• Molecular Formula: C₈H₈F₂O₂
• Molecular Weight: 174.147
• DSSTox Substance ID: DTXSID101300602
• Mol file: 75626-18-5.mol

Synonyms:1,4-difluoro-2,3-dimethoxybenzene;75626-18-5;Benzene, 1,4-difluoro-2,3-dimethoxy-;SCHEMBL9873091;DTXSID101300602;MFCD18394834;CS-0192564;E91516

Chemical Property of 1,4-Difluoro-2,3-dimethoxybenzene

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 174.04923582
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1OC)F)F

Technology Process of 1,4-Difluoro-2,3-dimethoxybenzene

There total 9 articles about 1,4-Difluoro-2,3-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3,6-difluoro-2-hydroxyanisole (75626-22-1) + dimethyl sulfate (77-78-1) → 1,4-difluoro-2,3-dimethoxybenzene (75626-18-5)

Guidance literature:

With potassium carbonate; In acetone;

DOI:10.1021/jo00314a054

Reference yield: 47.0%

3,6-Difluorocatechol (75626-23-2) + dimethyl sulfate (77-78-1) → 1,4-difluoro-2,3-dimethoxybenzene (75626-18-5)

Guidance literature:

With potassium carbonate; In acetone; for 3h; Reflux;

DOI:10.1016/j.bmcl.2010.07.057

Reference yield:

1,2,3,4-tetrafluorobenzene (551-62-2) → 1,4-difluoro-2,3-dimethoxybenzene (75626-18-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 42 percent / NaOH / 3.5 h / Heating

2: 42 percent / K₂CO₃ / dimethylformamide / Heating

3: 76 percent / AlCl₃ / toluene / 4.5 h / Heating

4: 44 percent / K₂CO₃ / acetone / 1.5 h / Heating

With sodium hydroxide; aluminium trichloride; potassium carbonate; In N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1021/jo00314a054

upstream raw materials:

3,6-Difluorocatechol

dimethyl sulfate

3,6-difluoro-2-hydroxyanisole

diazomethane

Downstream raw materials:

1,4-difluoro-2,3-dimethoxy-5-methylbenzene

1,2-<(diphenylmethylene)dioxy>-3-fluoro-4-methyl-5-nitro-6-piperidinobenzene

[(E)-2-(4,7-Difluoro-6-nitro-2,2-diphenyl-benzo[1,3]dioxol-5-yl)-vinyl]-dimethyl-amine

5,6-<(diphenylmethylene)dioxy>-4-fluoro-7-piperidinoindole