1-(Chloromethyl)-2,5-difluoro-3,4-dimethoxybenzene

Base Information

Chemical Name:1-(Chloromethyl)-2,5-difluoro-3,4-dimethoxybenzene
CAS No.:75626-19-6
Molecular Formula:C₉H₉ClF₂O₂
Molecular Weight:222.619
Hs Code.:
DSSTox Substance ID:DTXSID901228953

Synonyms:1-(Chloromethyl)-2,5-difluoro-3,4-dimethoxybenzene;DTXSID901228953;75626-19-6

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(Chloromethyl)-2,5-difluoro-3,4-dimethoxybenzene

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:222.0259135
Heavy Atom Count:14
Complexity:182

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1OC)F)CCl)F

Technology Process of 1-(Chloromethyl)-2,5-difluoro-3,4-dimethoxybenzene

There total 9 articles about 1-(Chloromethyl)-2,5-difluoro-3,4-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 75626-18-5
1,4-difluoro-2,3-dimethoxybenzene

: 75626-19-6
1-Chloromethyl-2,5-difluoro-3,4-dimethoxy-benzene

Guidance literature:: With hydrogenchloride; In acetic acid; 1.) 75 deg C, 7.5 h, 2.) room temp. overnight, 3.) heating, 4.5 h;
DOI:10.1021/jo00314a054

Reference yield:

: 551-62-2
1,2,3,4-tetrafluorobenzene

: 75626-19-6
1-Chloromethyl-2,5-difluoro-3,4-dimethoxy-benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 42 percent / NaOH / 3.5 h / Heating

2: 42 percent / K₂CO₃ / dimethylformamide / Heating

3: 76 percent / AlCl₃ / toluene / 4.5 h / Heating

4: 44 percent / K₂CO₃ / acetone / 1.5 h / Heating

5: 95 percent / HCl / acetic acid / 1.) 75 deg C, 7.5 h, 2.) room temp. overnight, 3.) heating, 4.5 h

With hydrogenchloride; sodium hydroxide; aluminium trichloride; potassium carbonate; In acetic acid; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1021/jo00314a054

Reference yield:

: 540-36-3
para-difluorobenzene

: 75626-19-6
1-Chloromethyl-2,5-difluoro-3,4-dimethoxy-benzene

Guidance literature:: Multi-step reaction with 5 steps

2: 89 percent / K₂CO₃ / acetone / 2 h / Heating

4: 86 percent / K₂CO₃ / acetone

5: 95 percent / HCl / acetic acid / 1.) 75 deg C, 7.5 h, 2.) room temp. overnight, 3.) heating, 4.5 h

With hydrogenchloride; potassium carbonate; In acetic acid; acetone;
DOI:10.1021/jo00314a054