diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Base Information

Chemical Name:diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate
CAS No.:1351512-12-3
Molecular Formula:C₂₀H₂₄N₂O₄S
Molecular Weight:388.488
Hs Code.:

Synonyms:diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

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Chemical Property of diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

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Technology Process of diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

There total 4 articles about diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 404000-65-3
C₂₀H₂₂N₂O₄S

: 1351512-12-3
diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Guidance literature:: With sodium cyanoborohydride; In methanol; for 22h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.09.109

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 1351512-12-3
diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: morpholine; sulfur / ethanol / 20 - 40 °C

2: N-ethyl-N,N-diisopropylamine / methanol / 21 h / Molecular sieve; Reflux; Inert atmosphere

3: sodium cyanoborohydride / methanol / 22 h / Reflux; Inert atmosphere

With morpholine; sodium cyanoborohydride; sulfur; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; 1: Gewald reaction;
DOI:10.1016/j.bmcl.2011.09.109

Reference yield:

: 29976-53-2
N-ethoxycarbonyl-4-piperidone

: 1351512-12-3
diethyl 2-(benzylamino)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: morpholine; sulfur / ethanol / 20 - 40 °C

2: N-ethyl-N,N-diisopropylamine / methanol / 21 h / Molecular sieve; Reflux; Inert atmosphere

3: sodium cyanoborohydride / methanol / 22 h / Reflux; Inert atmosphere

With morpholine; sodium cyanoborohydride; sulfur; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; 1: Gewald reaction;
DOI:10.1016/j.bmcl.2011.09.109