(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

Base Information

Chemical Name:(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile
CAS No.:1297540-77-2
Molecular Formula:C₁₃H₁₂ClFN₄
Molecular Weight:278.716
Hs Code.:

Synonyms:(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

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Chemical Property of (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

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Technology Process of (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

There total 9 articles about (S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1297540-77-2
(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

Guidance literature:

Reference yield:

: 1297540-76-1
2-Chloro-6-fluoro-4-(1H-pyrazol-5-yl)benzonitrile

: 79069-13-9
(S)-2-t-butoxycarbonylaminopropan-1-ol

: 1297540-77-2
(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

Guidance literature:: 2-Chloro-6-fluoro-4-(1H-pyrazol-5-yl)benzonitrile; (S)-2-t-butoxycarbonylaminopropan-1-ol; With triphenylphosphine; In ethyl acetate; at 20 ℃; for 0.166667h; Inert atmosphere;

With di-isopropyl azodicarboxylate; In ethyl acetate; at 15 - 25 ℃; for 72h;

Reference yield:

: 1297540-76-1
2-chloro-6-fluoro-4-(1H-pyrazol-3-yl)benzonitrile

: 79069-13-9
(S)-2-t-butoxycarbonylaminopropan-1-ol

: 1297540-77-2
(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

Guidance literature:: 2-chloro-6-fluoro-4-(1H-pyrazol-3-yl)benzonitrile; (S)-2-t-butoxycarbonylaminopropan-1-ol; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 24h;
DOI:10.1016/j.ejmech.2019.111608