(S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide

Base Information

Chemical Name:(S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide
CAS No.:1403332-70-6
Molecular Formula:C₁₈H₁₄BrClFN₅O₂
Molecular Weight:466.697
Hs Code.:

Synonyms:(S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide

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Chemical Property of (S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide

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Technology Process of (S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide

There total 5 articles about (S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1297540-77-2
(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

: 95312-11-1
5-(bromomethyl)-3-isoxazolecarboxylic acid

: 1403332-70-6
(S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide

Guidance literature:: 5-(bromomethyl)-3-isoxazolecarboxylic acid; With dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 20 ℃;

(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile; With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 1297540-77-2
(S)-4-(1-(2-aminopropyl)-1H-pyrazol-3-yl)-2-chloro-6-fluorobenzonitrile

: 538-75-0
dicyclohexyl-carbodiimide

: 95312-11-1
5-(bromomethyl)-3-isoxazolecarboxylic acid

: 1403332-70-6
(S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield:

: 84654-29-5
5-(bromomethyl)-3-isoxazolecarboxylic acid ethyl ester

: 1403332-70-6
(S)-5-(Bromomethyl)-N-(1-(3-(3-chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)propan-2-yl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 0.5 h / 20 °C

1.2: pH 4

2.1: dicyclohexyl-carbodiimide / dichloromethane; tetrahydrofuran / 20 °C

2.2: 20 °C / Inert atmosphere

With water; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; dichloromethane;