N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Base Information

Chemical Name:N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide
CAS No.:1360622-01-0
Molecular Formula:C₃₀H₃₄Cl₂F₅N₅O₃
Molecular Weight:678.53
Hs Code.:

N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Synonyms:N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

There total 19 articles about N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1360624-01-6
N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide

: 1242269-83-5
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide

: 1360622-01-0
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide; N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide; In N,N-dimethyl-formamide; for 3h;

With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: C₃₀H₃₆Cl₂F₅N₅O₃S

: 1360622-01-0
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: With diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: 601-88-7
2,6-dichloronitrobenzene

: 1360622-01-0
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2-difluoro-ethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 75 °C

2.1: sodium hydroxide; methanol / 4 h / Reflux

3.1: triethylamine / tetrahydrofuran

4.1: hydrogen / Ra-Ni / tetrahydrofuran / 7 h / 2585.81 Torr

5.1: 1,4-dioxane / 10 h / 20 °C / Reflux

6.1: N,N-dimethyl-formamide / 3 h

6.2: 2 h / 80 °C

With methanol; sulfuric acid; hydrogen; triethylamine; sodium hydroxide; Ra-Ni; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;