N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide

Base Information

Chemical Name:N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide
CAS No.:1242269-83-5
Molecular Formula:C₁₇H₂₂F₅N₃O₂
Molecular Weight:395.373
Hs Code.:

Synonyms:N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide

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Chemical Property of N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide

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Technology Process of N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide

There total 8 articles about N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1242270-11-6
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-nitro-benzoic acid amide

: 1242269-83-5
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 4h; under 2585.81 Torr;

Reference yield:

: 133261-33-3
trans-4-trifluoro-methyl-cyclohexanecarboxylic acid

: 1242269-83-5
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 1.5 h / Reflux

2.1: ammonia / tetrahydrofuran / 0.08 h

3.1: sodium hydroxide; bromine / water / 3.75 h / 20 °C / Reflux

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 0.25 h

5.1: potassium tert-butylate / tetrahydrofuran / 0.25 h

5.2: 1.5 h

6.1: hydrogen / palladium on activated charcoal / methanol / 4 h / 2585.81 Torr

With thionyl chloride; potassium tert-butylate; ammonia; hydrogen; bromine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium on activated charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 933781-52-3
trans-4-(trifluoromethyl)cyclohexanecarboxamide

: 1242269-83-5
N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-amino-benzoic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; bromine / water / 3.75 h / 20 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 0.25 h

3.1: potassium tert-butylate / tetrahydrofuran / 0.25 h

3.2: 1.5 h

4.1: hydrogen / palladium on activated charcoal / methanol / 4 h / 2585.81 Torr

With potassium tert-butylate; hydrogen; bromine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; water;