6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol

Base Information

Chemical Name:6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol
CAS No.:736926-06-0
Molecular Formula:C₃₁H₃₃NO₄S
Molecular Weight:515.673
Hs Code.:

Synonyms:6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol

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Chemical Property of 6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol

Chemical Property:

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Technology Process of 6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol

There total 8 articles about 6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 648905-84-4
[2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane

: 736926-06-0
6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol

Guidance literature:: With pyridine hydrochloride; at 200 ℃; for 2h;
DOI:10.1021/jm050723z

Reference yield:

: 649724-98-1
(2-hydroxy-6-methoxy-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

: 736926-06-0
6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

2: 100 percent / Ph₃P; Pd(OAc)2; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 4 h / Heating

3: 92 percent / lithium aluminum hydride / tetrahydrofuran

4: 63 percent / Et₃SiH; trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

5: pyridine hydrochloride / 2 h / 200 °C

With pyridine; triethylsilane; palladium diacetate; lithium aluminium tetrahydride; pyridine hydrochloride; sodium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 2: Suzuki cross-coupling;
DOI:10.1021/jm050723z

Reference yield:

: 648905-80-0
(2,6-dimethoxynaphthalen-1-yl)-[4-(2-piperidin-1-ylethoxy)phenyl]methanone

: 736926-06-0
6-(4-methanesulfonylphenyl)-5-[4-(2-piperidin-1-ylethoxy)benzyl]naphthalen-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / BCl₃ / CH₂Cl₂ / 1 h / cooling

2: 100 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

3: 100 percent / Ph₃P; Pd(OAc)2; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 4 h / Heating

4: 92 percent / lithium aluminum hydride / tetrahydrofuran

5: 63 percent / Et₃SiH; trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

6: pyridine hydrochloride / 2 h / 200 °C

With pyridine; triethylsilane; palladium diacetate; lithium aluminium tetrahydride; pyridine hydrochloride; boron trichloride; sodium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 3: Suzuki cross-coupling;
DOI:10.1021/jm050723z