[2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane

Base Information

Chemical Name:[2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane
CAS No.:648905-84-4
Molecular Formula:C₃₂H₃₅NO₄S
Molecular Weight:529.7
Hs Code.:

Synonyms:[2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane

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Chemical Property of [2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane

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Technology Process of [2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane

There total 7 articles about [2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 648905-83-3
[2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanol

: 648905-84-4
[2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm050723z

Reference yield:

: 649724-98-1
(2-hydroxy-6-methoxy-naphthalen-1-yl)-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

: 648905-84-4
[2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

2: 100 percent / Ph₃P; Pd(OAc)2; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 4 h / Heating

3: 92 percent / lithium aluminum hydride / tetrahydrofuran

4: 63 percent / Et₃SiH; trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With pyridine; triethylsilane; palladium diacetate; lithium aluminium tetrahydride; sodium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 2: Suzuki cross-coupling;
DOI:10.1021/jm050723z

Reference yield:

: 648905-80-0
(2,6-dimethoxynaphthalen-1-yl)-[4-(2-piperidin-1-ylethoxy)phenyl]methanone

: 648905-84-4
[2-(4-methanesulfonylphenyl)-6-methoxynaphthalen-1-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methane

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / BCl₃ / CH₂Cl₂ / 1 h / cooling

2: 100 percent / pyridine / CH₂Cl₂ / 0.25 h / 0 °C

3: 100 percent / Ph₃P; Pd(OAc)2; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 4 h / Heating

4: 92 percent / lithium aluminum hydride / tetrahydrofuran

5: 63 percent / Et₃SiH; trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With pyridine; triethylsilane; palladium diacetate; lithium aluminium tetrahydride; boron trichloride; sodium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 3: Suzuki cross-coupling;
DOI:10.1021/jm050723z