trans-4-(Carbobenzoxyamino)cyclohexanecarboxylic Acid

Base Information

• Chemical Name: trans-4-(Carbobenzoxyamino)cyclohexanecarboxylic Acid
• CAS No.: 220851-34-3
• Molecular Formula: C15H19 N O4
• Molecular Weight: 277.32
• NSC Number: 142050
• DSSTox Substance ID: DTXSID30986560
• Nikkaji Number: J2.646.096D
• ChEMBL ID: CHEMBL1544766,CHEMBL1586657,CHEMBL1905999
• Mol file: 220851-34-3.mol

Synonyms:34771-04-5;67299-52-9;trans-4-(Carbobenzoxyamino)cyclohexanecarboxylic Acid;4-(phenylmethoxycarbonylamino)cyclohexane-1-carboxylic acid;Z-Trans-4-aminocyclohexanecarboxylic acid;220851-34-3;MLS000038274;MLS002920538;trans-4-(benzyloxycarbonylamino)cyclohexanecarboxylic acid;cis-4-(((Benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid;trans-4-(((Benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid;4-Benzyloxycarbonylamino-cyclohexanecarboxylic acid;SMR000038295;cis-4-(carbobenzoxyamino)cyclohexanecarboxylic acid;cis-4-benzyloxycarbonylaminocyclohexanecarboxylic acid;trans-4-benzyloxycarbonylaminocyclohexanecarboxylic acid;trans-4-benzyloxycarbonylamino-cyclohexanecarboxylic acid;(1s,4s)-4-(benzyloxycarbonylamino)cyclohexanecarboxylic acid;cis-4-(((Benzyloxy)carbonyl)amino)cyclohexane-1-carboxylic acid;CIS-1-(BENZYLOXYCARBONYL-AMINO)CYCLOHEXYL-4-CARBOXYLIC ACID;(1R,4R)-4-{[(BENZYLOXY)CARBONYL]AMINO}CYCLOHEXANE-1-CARBOXYLIC ACID;(1S,4S)-4-{[(BENZYLOXY)CARBONYL]AMINO}CYCLOHEXANE-1-CARBOXYLIC ACID;trans-4-(Cbz-amino)cyclohexanecarboxylic Acid;Z-1,4-trans-ACHC-OH;cis-4-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid;trans-4-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid;cis-4-Benzyloxycarbonylaminocyclohexane-carboxylic acid;Oprea1_754808;MLS000551309;SCHEMBL861653;SCHEMBL861654;SCHEMBL895622;cid_285247;CHEMBL1544766;CHEMBL1586657;CHEMBL1905999;SCHEMBL13526598;SCHEMBL17273007;BDBM68392;DTXSID30986560;HMS2156E24;HMS2303N22;HMS3321N14;AMY41322;AMY41323;MFCD01550737;MFCD01880738;NSC142050;STK525137;AKOS005459109;AKOS027250688;NSC-142050;AS-39309;SMR000145235;SMR001798127;C2036;CS-0130595;CS-0130644;EN300-4243458;EN300-4753885;EN300-6249752;A874865;4-(benzyloxycarbonylamino)cyclohexanecarboxylic acid;A1-51515;cis-4-benzyloxycarbonylamino-cyclohexanecarboxylic acid;cis-4-benzyloxycarbonylaminocyclohexane carboxylic acid;N-carbobenzoxy-trans-4-aminocyclohexanecarboxylic acid;Z565902152;(trans)-4-(benzyloxycarbonylamino)cyclohexanecarboxylic acid;4-(phenylmethoxycarbonylamino)-1-cyclohexanecarboxylic acid;4-{[(benzyloxy)carbonyl]amino}cyclohexane-1-carboxylic acid;(1r,4r)-4-(benzyloxycarbonylamino)cyclohexanecarboxylic acid;trans-4-(((Benzyloxy)carbonyl)amino)cyclohexanecarboxylicacid;trans-4-{[(Benzyloxy)carbonyl]amino}cyclohexane carboxylic acid;TRANS-1-(BENZYLOXYCARBONYLAMINO)CYCLOHEXYL-4-CARBOXYLIC ACID;4-{[(Benzyloxy)(hydroxy)methylidene]amino}cyclohexane-1-carboxylic acid;trans-(1r,4r)-4-(((Benzyloxy)carbonyl)amino)cyclohexane-1-carboxylic acid

Chemical Property of trans-4-(Carbobenzoxyamino)cyclohexanecarboxylic Acid

Chemical Property:

• PSA: 75.63000
• LogP: 2.94710
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 277.13140809
• Heavy Atom Count: 20
• Complexity: 331

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CCC1C(=O)O)NC(=O)OCC2=CC=CC=C2

Technology Process of trans-4-(Carbobenzoxyamino)cyclohexanecarboxylic Acid

There total 4 articles about trans-4-(Carbobenzoxyamino)cyclohexanecarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-aminocyclohexanecarboxylic acid (1776-53-0) + dibenzyl dicarbonate (31139-36-3) → cis/trans-4-benzyloxycarbonylamino-cyclohexanecarboxylic acid (220851-34-3)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water;

Reference yield: 75.0%

4-aminocyclohexanecarboxylic acid (1776-53-0) + dibenzyl dicarbonate (31139-36-3) → 3-{1-[(cis-4-{5-Indanyloxycarbonyl}cyclohexyl)carbamoyl]cyclopentyl}-2-(2-methoxyethoxy)propanoic acid + cis/trans-4-benzyloxycarbonylamino-cyclohexanecarboxylic acid (220851-34-3)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water;

Reference yield: 59.0%

4-aminocyclohexanecarboxylic acid (1776-53-0) + benzyl chloroformate (501-53-1,94274-21-2) → cis/trans-4-benzyloxycarbonylamino-cyclohexanecarboxylic acid (220851-34-3)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 ℃; for 3h;

upstream raw materials:

4-aminocyclohexanecarboxylic acid

benzyl chloroformate

dibenzyl dicarbonate

(1R,4R)-4-aminocyclohexanecarboxylic acid hydrochloride

Downstream raw materials:

4-[2-(2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-cyclohexanecarboxylic acid (2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-3a-ylmethyl)-amide

C₁₉H₃₂N₂O₆

C₂₇H₃₈N₂O₈

trans-4-benzyloxycarbonyl-amino-N-(2-hydroxyphenyl)cyclohexanecarboxamide

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