{4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester
• CAS No.: 138848-78-9
• Molecular Formula: C₄₂H₄₆N₄O₇
• Molecular Weight: 718.85

Synonyms:{4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester

Chemical Property of {4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester

Chemical Property:

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Technology Process of {4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester

There total 3 articles about {4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis/trans-4-benzyloxycarbonylamino-cyclohexanecarboxylic acid (220851-34-3) → {4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester (138848-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: Et₃N / CHCl₃; dimethylformamide / Ambient temperature

With thionyl chloride; triethylamine; In chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.2340

Reference yield:

[(S)-5-(4-Benzoyl-phenylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid benzyl ester (103892-91-7) → {4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester (138848-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 5.6 N HCl / dioxane

2: Et₃N / CHCl₃; dimethylformamide / Ambient temperature

With hydrogenchloride; triethylamine; In 1,4-dioxane; chloroform; N,N-dimethyl-formamide;

DOI:10.1248/cpb.39.2340

Reference yield:

trans-4-(benzyl-oxycarbonylamino)cyclohexane carboxylic acid chloride + [(S)-5-Amino-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride (103917-70-0) → {4-[(S)-1-(4-Benzoyl-phenylcarbamoyl)-5-benzyloxycarbonylamino-pentylcarbamoyl]-cyclohexyl}-carbamic acid benzyl ester (138848-78-9)

Guidance literature:

With triethylamine; In chloroform; N,N-dimethyl-formamide; Yield given; Ambient temperature;

DOI:10.1248/cpb.39.2340

upstream raw materials:

[(S)-5-Amino-5-(4-benzoyl-phenylcarbamoyl)-pentyl]-carbamic acid benzyl ester; hydrochloride

cis/trans-4-benzyloxycarbonylamino-cyclohexanecarboxylic acid

[(S)-5-(4-Benzoyl-phenylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid benzyl ester

Downstream raw materials:

4-Amino-cyclohexanecarboxylic acid [(S)-5-amino-1-(4-benzoyl-phenylcarbamoyl)-pentyl]-amide

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