2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester

Base Information

Chemical Name:2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester
CAS No.:135219-44-2
Molecular Formula:C₄₁H₅₉N₅O₉
Molecular Weight:765.948
Hs Code.:

2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester

Synonyms:2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester

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Chemical Property of 2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester

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Technology Process of 2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester

There total 10 articles about 2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.4%

: 135219-71-5
(S)-2-((R)-2-{(2R,3S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyrylamino]-2-hydroxy-pentanoylamino}-4-methyl-pentanoylamino)-3-methyl-butyric acid benzyl ester

: 135219-44-2
2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester

Guidance literature:: With pyridinium trifluroacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; for 24h; Ambient temperature;
DOI:10.7164/antibiotics.49.287

Reference yield:

: 3918-94-3
Val-Val

: 135219-44-2
2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / Na₂CO₃ / H₂O; dioxane / 18 h / 20 °C

2.1: H₂ / Pd/C / ethyl acetate / 5 h / 20 °C

2.2: 69 percent / HOBt; Et₃N; EDCI / ethyl acetate; CH₂Cl₂ / 2.17 h / 0 - 20 °C

3.1: O₃ / CH₂Cl₂ / -78 °C

3.2: 0.3 g / CH₂Cl₂ / 1 h / -78 °C

With hydrogen; sodium carbonate; ozone; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; water; ethyl acetate;
DOI:10.1016/S0040-4020(03)00860-3

Reference yield:

: 19542-54-2
N-benzyloxycarbonyl-L-valyl-L-valine

: 135219-44-2
2-(2-{3-[2-(2-benzyloxycarbonylamino-3-methylbutyrylamino)-3-methyl-butyrylamino]-2-oxo-pentanoylamino}-4-methylpentanoylamino)-3-methylbutyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂ / Pd/C / ethyl acetate / 5 h / 20 °C

1.2: 69 percent / HOBt; Et₃N; EDCI / ethyl acetate; CH₂Cl₂ / 2.17 h / 0 - 20 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 0.3 g / CH₂Cl₂ / 1 h / -78 °C

With hydrogen; ozone; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4020(03)00860-3