N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide

Base Information

• Chemical Name: N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide
• CAS No.: 1500082-10-9
• Molecular Formula: C₃₆H₃₇N₃O₅
• Molecular Weight: 591.707
• Mol file: 1500082-10-9.mol

Synonyms:N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide

Chemical Property of N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide

There total 2 articles about N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) → N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide (1500082-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic anhydride; sodium acetate / 3 h / Reflux

2.1: methanol / 0.5 h / 20 °C

2.2: 46 h / 20 °C

With sodium acetate; acetic anhydride; In methanol; 1.1: |Erlenmeyer-Plochl-Bergmann;

DOI:10.1246/bcsj.20130106

Reference yield:

4-Carboxybenzaldehyde (619-66-9) → N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide (1500082-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic anhydride; sodium acetate / 3 h / Reflux

2.1: methanol / 0.5 h / 20 °C

2.2: 46 h / 20 °C

With sodium acetate; acetic anhydride; In methanol; 1.1: |Erlenmeyer-Plochl-Bergmann;

DOI:10.1246/bcsj.20130106

Reference yield: 88.0%

2-azido-N-benzyl-N-{2-[(tert-butyl)amino]-1-(2-chlorophenyl)-2-oxoethyl}-2-acetamide (1370471-18-3) + N-((tert-butylcarbamoyl)(2-(prop-2-ynyloxy)phenyl)methyl)-N-butyl-4-((7Z)-(5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzamide (1500082-10-9) → C57H61ClN8O7

Guidance literature:

With copper(ll) sulfate pentahydrate; water; sodium L-ascorbate; tert-butyl alcohol; In dimethyl sulfoxide; at 20 ℃; for 24h;

DOI:10.1246/bcsj.20130106

upstream raw materials:

4-Carboxybenzaldehyde

Hippuric Acid