methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate

Base Information

Chemical Name:methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate
CAS No.:1446266-64-3
Molecular Formula:C₂₀H₁₈BrN₃O₄
Molecular Weight:444.285
Hs Code.:

Synonyms:methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate

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Chemical Property of methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate

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Technology Process of methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate

There total 1 articles about methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1279845-56-5
2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]benzoic acid

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 1446266-64-3
methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate

Guidance literature:: 2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]benzoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 0.5h; Inert atmosphere;

glycine ethyl ester hydrochloride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

Reference yield:

: 1446266-64-3
methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate

: 541-41-3
chloroformic acid ethyl ester

: C₂₃H₂₂BrN₃O₆

Guidance literature:: With pyridine; at 0 - 20 ℃; for 0.25h;

Reference yield:

: 1446266-64-3
methyl N-({2-amino-5-[(1-bromo-2-methylindolizin-3-yl)carbonyl]phenyl}carbonyl)glycinate

: 1446266-69-8
methyl [6-({1-[4-(2-tert-butoxy-2-oxoethoxy)phenyl]-2-methylindolizin-3-yl}carbonyl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 0.25 h / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 1 h / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / monoethylene glycol diethyl ether; aq. phosphate buffer / 2 h / Inert atmosphere; Reflux

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; aq. phosphate buffer; monoethylene glycol diethyl ether;