N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide

Base Information

Chemical Name:N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide
CAS No.:852660-89-0
Molecular Formula:C₃₃H₄₇FN₈O₂
Molecular Weight:606.787
Hs Code.:

N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide

Synonyms:N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide

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Chemical Property of N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide

Chemical Property:

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Technology Process of N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide

There total 8 articles about N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 852660-89-0
N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: tetrahydrofuran / 16 h / 0 - 20 °C

3: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 4 h / 0 - 25 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 2 h / 25 °C / Heating / reflux

5: hydrogen / palladium dihydroxide / methanol / 4 h / 2585.81 Torr

6: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / 0 - 25 °C

7: triethylamine / tetrahydrofuran / 18 h / 20 °C

With 2,6-dimethylpyridine; sodium azide; oxalyl dichloride; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

Reference yield:

: C₂₂H₃₆FN₃O

: 675122-49-3
phenyl 3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenylcarbamate

: 852660-89-0
N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 90050-52-5
3-bromo-N-methyl-5-nitrobenzamide

: 852660-89-0
N-{(1R,3R,4S)-4-{[[2,2-dimethyl-3-(4-fluorophenyl)propyl](methyl)amino]methyl}-3-[({[3-ethyl-5-(1-methyl-1H-tetrazol-5-yl)phenyl]amino}carbonyl)amino]cyclohexyl}-N-methylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide; trifluoromethylsulfonic anhydride / acetonitrile / 4 h / 0 - 25 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 2 h / 25 °C / Heating / reflux

3: hydrogen / palladium dihydroxide / methanol / 4 h / 2585.81 Torr

4: 2,6-dimethylpyridine / tetrahydrofuran / 1 h / 0 - 25 °C

5: triethylamine / tetrahydrofuran / 18 h / 20 °C

With 2,6-dimethylpyridine; sodium azide; trifluoromethylsulfonic anhydride; hydrogen; triethylamine; palladium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; acetonitrile;