(R)-3-(1-Amino-1-methylethyl)-1-benzylpyrrolidine

Base Information

Chemical Name:(R)-3-(1-Amino-1-methylethyl)-1-benzylpyrrolidine
CAS No.:157528-57-9
Molecular Formula:C₁₄H₂₂N₂
Molecular Weight:218.342
Hs Code.:
DSSTox Substance ID:DTXSID401189734

Synonyms:SCHEMBL607895;DTXSID401189734;(R)-3-(1-Amino-1-methylethyl)-1-benzylpyrrolidine;(3R)-alpha,alpha-Dimethyl-1-(phenylmethyl)-3-pyrrolidinemethanamine;157528-57-9

Suppliers and Price of (R)-3-(1-Amino-1-methylethyl)-1-benzylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(1-Amino-1-methylethyl)-1-benzylpyrrolidine

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:218.178298710
Heavy Atom Count:16
Complexity:219

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C1CCN(C1)CC2=CC=CC=C2)N
Isomeric SMILES:CC(C)([C@@H]1CCN(C1)CC2=CC=CC=C2)N

Technology Process of (R)-3-(1-Amino-1-methylethyl)-1-benzylpyrrolidine

There total 3 articles about (R)-3-(1-Amino-1-methylethyl)-1-benzylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1336-21-6
ammonium hydroxide

: 157528-56-8
(R)-1-benzylpyrrolidine-3-carbonitrile

: 351362-84-0
1-((R)-methyl-1-pyrrolidin-3-yl)-ethylamine

: 157528-57-9
(R)-3-(1-amino-1-methylethyl)-1-benzylpyrrolidine

Guidance literature:: With methyllithium; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid;

Reference yield:

: 917-54-4
methyllithium

: 157528-56-8
(R)-1-benzylpyrrolidine-3-carbonitrile

: 157528-57-9
(R)-3-(1-amino-1-methylethyl)-1-benzylpyrrolidine

Guidance literature:: With cerium(III) chloride; Yield given. Multistep reaction; 1.) THF, 2.) THF, diethyl ether, from -70 deg C to -60 deg C, 3 h;
DOI:10.1016/0957-4166(94)80138-X