5H-Indeno[1,2-b]quinolin-10(11H)-one

Base Information

• Chemical Name: 5H-Indeno[1,2-b]quinolin-10(11H)-one
• CAS No.: 38105-54-3
• Molecular Formula: C₁₆H₁₁NO
• Molecular Weight: 233.269
• European Community (EC) Number: 668-074-2
• Nikkaji Number: J3.449.850D
• Mol file: 38105-54-3.mol

Synonyms:5H-Indeno[1,2-b]quinolin-10(11H)-one;38105-54-3;5H-INDENO(1,2-B)QUINOLIN-10(11H)-ONE;5,11-dihydro-10H-indeno[1,2-b]quinolin-10-one;SCHEMBL7746281;AKOS015906052;5H-Indeno[1,2-b]quinoline-10(11H)-one;5,11-dihydro-indeno[3,2-b]quinolin-10-one

Chemical Property of 5H-Indeno[1,2-b]quinolin-10(11H)-one

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 233.084063974
• Heavy Atom Count: 18
• Complexity: 411

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C2=CC=CC=C2C3=C1C(=O)C4=CC=CC=C4N3

Technology Process of 5H-Indeno[1,2-b]quinolin-10(11H)-one

There total 1 articles about 5H-Indeno[1,2-b]quinolin-10(11H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

3,4:8,9-Dibenzo-1-azacyclonona-3,8-dien-2,7-dion (35639-24-8) + benzaldehyde (100-52-7) → 5H-indeno[1,2-b]quinolin-10(11H)-one (38105-54-3) + 12-benzylidene-11,12-dihydro-5H-dibenzo[b,g]azonine-6,13-dione

Guidance literature:

With piperidine; In ethanol; for 2h; Reflux;

DOI:10.1515/znb-2014-0271

Reference yield: 86.0%

5H-indeno[1,2-b]quinolin-10(11H)-one (38105-54-3) → 10-chloro-11H-indeno-[1,2-b]-quinoline (35639-26-0)

Guidance literature:

With trichlorophosphate; at 110 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2019.02.072

Reference yield:

5H-indeno[1,2-b]quinolin-10(11H)-one (38105-54-3) → 11H-indeno[1,2-b]quinoline (243-51-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / POCl₃ / 3 h / 110 °C

2: 85 percent / H₂ / Pd-C / tetrahydrofuran / 6 h / 2585.74 Torr

With hydrogen; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1016/j.bmc.2006.10.062

upstream raw materials:

3,4:8,9-Dibenzo-1-azacyclonona-3,8-dien-2,7-dion

benzaldehyde

Downstream raw materials:

10-chloro-11H-indeno-[1,2-b]-quinoline

11H-indeno[1,2-b]quinoline