tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate
• CAS No.: 1207438-67-2
• Molecular Formula: C₁₈H₂₄Cl₂N₂O₃
• Molecular Weight: 387.306

Synonyms:tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate

Chemical Property of tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

tert-butyl 4-[(RS)-cyano(3,4-dichlorophenyl)methyl]piperidine-1-carboxylate (1207438-43-4) → tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate (1207438-67-2)

Guidance literature:

With water; sodium hydroxide; In ethanol; for 4h; Reflux;

DOI:10.1016/j.bmc.2013.05.025

Reference yield:

3,4-dichloro-benzeneacetonitrile (3218-49-3) → tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate (1207438-67-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

3: water; sodium hydroxide / ethanol / 4 h / Reflux

With sodium tetrahydroborate; water; sodium methylate; sodium hydroxide; In methanol; ethanol;

DOI:10.1016/j.bmc.2013.05.025

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate (1207438-67-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / 2 h / Reflux

2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

3: water; sodium hydroxide / ethanol / 4 h / Reflux

With sodium tetrahydroborate; water; sodium methylate; sodium hydroxide; In methanol; ethanol;

DOI:10.1016/j.bmc.2013.05.025

upstream raw materials:

tert-butyl 4-[(RS)-cyano(3,4-dichlorophenyl)methyl]piperidine-1-carboxylate

3,4-dichloro-benzeneacetonitrile

N-tert-butyloxycarbonylpiperidin-4-one

tert-butyl 4-[cyano(3,4-dichlorophenyl)methylidene]piperidine-1-carboxylate

Downstream raw materials:

tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate

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