tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate
• CAS No.: 1207438-69-4
• Molecular Formula: C₂₀H₂₈Cl₂N₂O₃
• Molecular Weight: 415.36

Synonyms:tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate

Chemical Property of tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate (1207438-67-2) + methyl iodide (74-88-4) → tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate (1207438-69-4)

Guidance literature:

tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.0833333h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

DOI:10.1016/j.bmc.2013.05.025

Reference yield: 79.0%

tert-butyl 4-[(1RS)-1-(3,4-dichlorophenyl)-2-(dimethylamino)-2-oxoethyl]piperidine-1-carboxylate (1207438-69-4) → (2RS)-2-(3,4-dichlorophenyl)-N,N-dimethyl-2-(piperidin-4-yl)ethanamide monohydrochloride (1207436-29-0)

Guidance literature:

With hydrogenchloride; ethanol; at 20 ℃; for 0.25h;

DOI:10.1016/j.bmc.2013.05.025

upstream raw materials:

tert-butyl 4-[(1RS)-2-amino-1-(3,4-dichlorophenyl)-2-oxoethyl]piperidine-1-carboxylate

methyl iodide

Downstream raw materials:

(2RS)-2-(3,4-dichlorophenyl)-N,N-dimethyl-2-(piperidin-4-yl)ethanamide monohydrochloride

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